Iron-catalyzed indolizine synthesis from pyridines, diazo compounds, and alkynes
The iron (III) catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction is compatib...
| Main Authors: | , , |
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| Format: | Article |
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American Chemical Society
2017
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| Online Access: | https://eprints.nottingham.ac.uk/48261/ |
| _version_ | 1848797726303584256 |
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| author | Douglas, Tim Pordea, Anca Dowden, James |
| author_facet | Douglas, Tim Pordea, Anca Dowden, James |
| author_sort | Douglas, Tim |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The iron (III) catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction is compatible with electrophilic alkynes; control experiments demonstrate the importance of the catalyst in promoting pyridinium ylide formation over background reactivity. |
| first_indexed | 2025-11-14T20:08:27Z |
| format | Article |
| id | nottingham-48261 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:08:27Z |
| publishDate | 2017 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-482612020-05-04T19:17:44Z https://eprints.nottingham.ac.uk/48261/ Iron-catalyzed indolizine synthesis from pyridines, diazo compounds, and alkynes Douglas, Tim Pordea, Anca Dowden, James The iron (III) catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction is compatible with electrophilic alkynes; control experiments demonstrate the importance of the catalyst in promoting pyridinium ylide formation over background reactivity. American Chemical Society 2017-11-16 Article PeerReviewed Douglas, Tim, Pordea, Anca and Dowden, James (2017) Iron-catalyzed indolizine synthesis from pyridines, diazo compounds, and alkynes. Organic Letters, 19 (23). pp. 6396-6399. ISSN 1523-7052 http://pubs.acs.org/doi/10.1021/acs.orglett.7b03252 doi:10.1021/acs.orglett.7b03252 doi:10.1021/acs.orglett.7b03252 |
| spellingShingle | Douglas, Tim Pordea, Anca Dowden, James Iron-catalyzed indolizine synthesis from pyridines, diazo compounds, and alkynes |
| title | Iron-catalyzed indolizine synthesis from pyridines, diazo
compounds, and alkynes |
| title_full | Iron-catalyzed indolizine synthesis from pyridines, diazo
compounds, and alkynes |
| title_fullStr | Iron-catalyzed indolizine synthesis from pyridines, diazo
compounds, and alkynes |
| title_full_unstemmed | Iron-catalyzed indolizine synthesis from pyridines, diazo
compounds, and alkynes |
| title_short | Iron-catalyzed indolizine synthesis from pyridines, diazo
compounds, and alkynes |
| title_sort | iron-catalyzed indolizine synthesis from pyridines, diazo
compounds, and alkynes |
| url | https://eprints.nottingham.ac.uk/48261/ https://eprints.nottingham.ac.uk/48261/ https://eprints.nottingham.ac.uk/48261/ |