A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition

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A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition

The microtubule depolymerising kinesin-13, MCAK, is phosphorylated at residue T537 by Cdk1. This is the only known phosphorylation site within MCAK’s motor domain. To understand the impact of phosphorylation by Cdk1 on microtubule depolymerisation activity, we have investigated the molecular mechani...

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Bibliographic Details
Main Authors:	Belsham, Hannah R., Friel, Claire T.
Format:	Article
Published:	PeerJ 2017
Subjects:	MCAK; kinesin-13; Microtubule; Depolymerisation; Microtubule end recognition; Phosphomimic
Online Access:	https://eprints.nottingham.ac.uk/48216/

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