Cannabinoid-mediated short-term plasticity in hippocampus
Endocannabinoids modulate both excitatory and inhibitory neurotransmission in hippocampus via activation of pre-synaptic cannabinoid receptors. Here, we present a model for cannabinoid mediated short-term depression of excitation (DSE) based on our recently developed model for the equivalent phenom...
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| Format: | Article |
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Springer Verlag
2014
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| Online Access: | https://eprints.nottingham.ac.uk/48173/ |
| _version_ | 1848797708909805568 |
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| author | Zachariou, Margarita Thul, Ruediger |
| author_facet | Zachariou, Margarita Thul, Ruediger |
| author_sort | Zachariou, Margarita |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Endocannabinoids modulate both excitatory and inhibitory neurotransmission in hippocampus via activation of pre-synaptic cannabinoid receptors. Here, we present a model for cannabinoid mediated short-term depression of excitation (DSE) based on our recently developed model for the equivalent phenomenon of suppressing inhibition (DSI). Furthermore, we derive a simplified formulation of the calcium-mediated endocannabinoid synthesis that underlies short-term modulation of neurotransmission in hippocampus. The simplified model describes cannabinoid-mediated short-term modulation of both hippocampal inhibition and excitation and is ideally suited for large network studies. Moreover, the implementation of the simplified DSI/DSE model provides predictions on how both phenomena are modulated by the magnitude of the pre-synaptic cell's activity. In addition we demonstrate the role of DSE in shaping the post-synaptic cell's firing behaviour qualitatively and quantitatively in dependence on eCB availability and the pre-synaptic cell's activity. Finally, we explore under which conditions the combination of DSI and DSE can temporarily shift the fine balance between excitation and inhibition. This highlights a mechanism by which eCBs might act in a neuro-protective manner during high neural activity. |
| first_indexed | 2025-11-14T20:08:11Z |
| format | Article |
| id | nottingham-48173 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:08:11Z |
| publishDate | 2014 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-481732020-05-04T16:52:22Z https://eprints.nottingham.ac.uk/48173/ Cannabinoid-mediated short-term plasticity in hippocampus Zachariou, Margarita Thul, Ruediger Endocannabinoids modulate both excitatory and inhibitory neurotransmission in hippocampus via activation of pre-synaptic cannabinoid receptors. Here, we present a model for cannabinoid mediated short-term depression of excitation (DSE) based on our recently developed model for the equivalent phenomenon of suppressing inhibition (DSI). Furthermore, we derive a simplified formulation of the calcium-mediated endocannabinoid synthesis that underlies short-term modulation of neurotransmission in hippocampus. The simplified model describes cannabinoid-mediated short-term modulation of both hippocampal inhibition and excitation and is ideally suited for large network studies. Moreover, the implementation of the simplified DSI/DSE model provides predictions on how both phenomena are modulated by the magnitude of the pre-synaptic cell's activity. In addition we demonstrate the role of DSE in shaping the post-synaptic cell's firing behaviour qualitatively and quantitatively in dependence on eCB availability and the pre-synaptic cell's activity. Finally, we explore under which conditions the combination of DSI and DSE can temporarily shift the fine balance between excitation and inhibition. This highlights a mechanism by which eCBs might act in a neuro-protective manner during high neural activity. Springer Verlag 2014-08-16 Article PeerReviewed Zachariou, Margarita and Thul, Ruediger (2014) Cannabinoid-mediated short-term plasticity in hippocampus. Journal of Computational Neuroscience, 37 (3). pp. 533-547. ISSN 1573-6873 Calcium DSI DSE Endocannabinoids Hippocampus Short-term Plasticity https://link.springer.com/article/10.1007/s10827-014-0518-4 doi:10.1007/s10827-014-0518-4 doi:10.1007/s10827-014-0518-4 |
| spellingShingle | Calcium DSI DSE Endocannabinoids Hippocampus Short-term Plasticity Zachariou, Margarita Thul, Ruediger Cannabinoid-mediated short-term plasticity in hippocampus |
| title | Cannabinoid-mediated short-term plasticity in hippocampus |
| title_full | Cannabinoid-mediated short-term plasticity in hippocampus |
| title_fullStr | Cannabinoid-mediated short-term plasticity in hippocampus |
| title_full_unstemmed | Cannabinoid-mediated short-term plasticity in hippocampus |
| title_short | Cannabinoid-mediated short-term plasticity in hippocampus |
| title_sort | cannabinoid-mediated short-term plasticity in hippocampus |
| topic | Calcium DSI DSE Endocannabinoids Hippocampus Short-term Plasticity |
| url | https://eprints.nottingham.ac.uk/48173/ https://eprints.nottingham.ac.uk/48173/ https://eprints.nottingham.ac.uk/48173/ |