Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students
Background In the UK rising disease levels due to Neisseria meningitidis serogroup W clonal complex ST-11 (MenW:cc11) strains led to introduction of conjugate MenACWY vaccination for teenagers. We investigated the impact of immunization on carriage of targeted meningococci by whole genome sequenc...
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| Format: | Article |
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Oxford University Press
2018
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| Online Access: | https://eprints.nottingham.ac.uk/48158/ |
| _version_ | 1848797705846915072 |
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| author | Oldfield, Neil J. Green, Luke R. Parkhill, Julian Bayliss, Christopher D. Turner, David P.J. |
| author_facet | Oldfield, Neil J. Green, Luke R. Parkhill, Julian Bayliss, Christopher D. Turner, David P.J. |
| author_sort | Oldfield, Neil J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
In the UK rising disease levels due to Neisseria meningitidis serogroup W clonal complex ST-11 (MenW:cc11) strains led to introduction of conjugate MenACWY vaccination for teenagers. We investigated the impact of immunization on carriage of targeted meningococci by whole genome sequencing of isolates recovered from a cohort of vaccinated university students.
Methods
Strain designation data were extracted from whole genome sequence data. Genomes from carried and invasive MenW:cc11 were compared using a gene-by-gene approach. Serogrouping identified isolates expressing capsule antigens targeted by the vaccine.
Results
Isolates with a W: P1.5,2: F1-1: ST-11 (cc11) designation, and belonging to the emerging ‘2013-strain’ of the South American-UK MenW:cc11 sub-lineage, were responsible for an increase in carried group W. A multifocal expansion was evident with close transmission networks extending beyond individual dormitories. Carried group Y isolates were predominantly from clonal complex 23, but showed significant heterogeneity and individual strain designations were only sporadically recovered. No shifts towards acapsulate phenotypes were detected in targeted meningococcal populations.
Conclusions
In a setting with high levels of conjugate MenACWY vaccination, expansion of capsule-expressing isolates from the 2013-strain of MenW:cc11, but not MenY:cc23 isolates, is indicative of differential susceptibilities to vaccine-induced immunity. |
| first_indexed | 2025-11-14T20:08:08Z |
| format | Article |
| id | nottingham-48158 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:08:08Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-481582020-05-04T19:29:28Z https://eprints.nottingham.ac.uk/48158/ Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students Oldfield, Neil J. Green, Luke R. Parkhill, Julian Bayliss, Christopher D. Turner, David P.J. Background In the UK rising disease levels due to Neisseria meningitidis serogroup W clonal complex ST-11 (MenW:cc11) strains led to introduction of conjugate MenACWY vaccination for teenagers. We investigated the impact of immunization on carriage of targeted meningococci by whole genome sequencing of isolates recovered from a cohort of vaccinated university students. Methods Strain designation data were extracted from whole genome sequence data. Genomes from carried and invasive MenW:cc11 were compared using a gene-by-gene approach. Serogrouping identified isolates expressing capsule antigens targeted by the vaccine. Results Isolates with a W: P1.5,2: F1-1: ST-11 (cc11) designation, and belonging to the emerging ‘2013-strain’ of the South American-UK MenW:cc11 sub-lineage, were responsible for an increase in carried group W. A multifocal expansion was evident with close transmission networks extending beyond individual dormitories. Carried group Y isolates were predominantly from clonal complex 23, but showed significant heterogeneity and individual strain designations were only sporadically recovered. No shifts towards acapsulate phenotypes were detected in targeted meningococcal populations. Conclusions In a setting with high levels of conjugate MenACWY vaccination, expansion of capsule-expressing isolates from the 2013-strain of MenW:cc11, but not MenY:cc23 isolates, is indicative of differential susceptibilities to vaccine-induced immunity. Oxford University Press 2018-01-30 Article PeerReviewed Oldfield, Neil J., Green, Luke R., Parkhill, Julian, Bayliss, Christopher D. and Turner, David P.J. (2018) Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students. Journal of Infectious Diseases, 217 (4). pp. 608-616. ISSN 1537-6613 Neisseria meningitidis; Whole genome sequencing; Carriage; Serogroup W; Serogroup Y; Epidemiology; Vaccine https://academic.oup.com/jid/article/4633891 doi:10.1093/infdis/jix596 doi:10.1093/infdis/jix596 |
| spellingShingle | Neisseria meningitidis; Whole genome sequencing; Carriage; Serogroup W; Serogroup Y; Epidemiology; Vaccine Oldfield, Neil J. Green, Luke R. Parkhill, Julian Bayliss, Christopher D. Turner, David P.J. Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students |
| title | Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students |
| title_full | Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students |
| title_fullStr | Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students |
| title_full_unstemmed | Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students |
| title_short | Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students |
| title_sort | limited impact of adolescent meningococcal acwy vaccination on neisseria meningitides serogroup w carriage in university students |
| topic | Neisseria meningitidis; Whole genome sequencing; Carriage; Serogroup W; Serogroup Y; Epidemiology; Vaccine |
| url | https://eprints.nottingham.ac.uk/48158/ https://eprints.nottingham.ac.uk/48158/ https://eprints.nottingham.ac.uk/48158/ |