Antimicrobial & antimicrobial resistance
By 2050, it is expected that antimicrobial resistance (AMR) will overtake cancer to become the world’s biggest killer. As the pharmaceutical industry spends less on antibiotic research and development, universities have an increasing role to play. As part of this degree, my two research projects app...
| Main Author: | |
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2017
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| Online Access: | https://eprints.nottingham.ac.uk/48146/ |
| _version_ | 1848797702935019520 |
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| author | Scales, Danielle |
| author_facet | Scales, Danielle |
| author_sort | Scales, Danielle |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | By 2050, it is expected that antimicrobial resistance (AMR) will overtake cancer to become the world’s biggest killer. As the pharmaceutical industry spends less on antibiotic research and development, universities have an increasing role to play. As part of this degree, my two research projects approach AMR from different angles. The first takes a traditional approach to AMR, and uses transposon mutagenesis to identify novel novobiocin resistance mechanisms in Klebsiella pneumoniae. The second takes a genotypic approach and explores the application of anti-virulence drugs, which inhibit IscR in Yersinia pseudotuberculosis to disarm rather than kill the bacteria. Diversification is essential for the development of novel antimicrobial strategies. |
| first_indexed | 2025-11-14T20:08:05Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-48146 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:08:05Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-481462025-02-28T13:56:02Z https://eprints.nottingham.ac.uk/48146/ Antimicrobial & antimicrobial resistance Scales, Danielle By 2050, it is expected that antimicrobial resistance (AMR) will overtake cancer to become the world’s biggest killer. As the pharmaceutical industry spends less on antibiotic research and development, universities have an increasing role to play. As part of this degree, my two research projects approach AMR from different angles. The first takes a traditional approach to AMR, and uses transposon mutagenesis to identify novel novobiocin resistance mechanisms in Klebsiella pneumoniae. The second takes a genotypic approach and explores the application of anti-virulence drugs, which inhibit IscR in Yersinia pseudotuberculosis to disarm rather than kill the bacteria. Diversification is essential for the development of novel antimicrobial strategies. 2017-12-12 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/48146/1/MRes.%20Thesis.pdf Scales, Danielle (2017) Antimicrobial & antimicrobial resistance. MRes thesis, University of Nottingham. |
| spellingShingle | Scales, Danielle Antimicrobial & antimicrobial resistance |
| title | Antimicrobial & antimicrobial resistance |
| title_full | Antimicrobial & antimicrobial resistance |
| title_fullStr | Antimicrobial & antimicrobial resistance |
| title_full_unstemmed | Antimicrobial & antimicrobial resistance |
| title_short | Antimicrobial & antimicrobial resistance |
| title_sort | antimicrobial & antimicrobial resistance |
| url | https://eprints.nottingham.ac.uk/48146/ |