Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS)
Background and purpose: Although poor prognosis after intracerebral haemorrhage relates to risk factors and haematoma characteristics, there is limited evidence for the effect of race-ethnicity. Methods: Data from 1011 patients with intracerebral haemorrhage enrolled into hyperacute trials and rand...
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| Format: | Article |
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Wiley
2018
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| Online Access: | https://eprints.nottingham.ac.uk/48048/ |
| _version_ | 1848797679110324224 |
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| author | Krishnan, Kailash Beishon, Lucy Berge, Eivind Christensen, Hanne Dineen, Robert A. Ozturk, Serefnur Sprigg, Nikola Wardlow, Joanna M. Bath, Philip M.W. |
| author_facet | Krishnan, Kailash Beishon, Lucy Berge, Eivind Christensen, Hanne Dineen, Robert A. Ozturk, Serefnur Sprigg, Nikola Wardlow, Joanna M. Bath, Philip M.W. |
| author_sort | Krishnan, Kailash |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background and purpose: Although poor prognosis after intracerebral haemorrhage relates to risk factors and haematoma characteristics, there is limited evidence for the effect of race-ethnicity.
Methods: Data from 1011 patients with intracerebral haemorrhage enrolled into hyperacute trials and randomised to control were obtained from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke (ENOS) Trial. Clinical characteristics and functional outcome were compared among three racial groups – Asians, Blacks and Caucasians.
Results: The majority of patients were Caucasian (78.1%) followed by Asians (14.5%) and Blacks (5.5%). At baseline, Caucasians were older and had larger haematoma volumes; Blacks had lower Glasgow Coma Scale and higher systolic blood pressure (all p<0.05). Although the primary outcome of modified Rankin scale (mRS) did not differ at 90 days (p=0.14), there were significant differences in mortality (p<0.0001) and quality of life (EQ-5D p<0.0001; EQ-VAS p 0.015). In test of multiple comparisons, Caucasians were more likely to die (p=0.0003) and had worse quality of life (EQ-5D p=0.003; EQ-VAS p<0.0001) as compared to Asians.
Conclusion: Race-ethnicity appears to explain some of the variation in clinical characteristics and outcomes after acute intracerebral haemorrhage. Factors that explain this variation need to be identified. |
| first_indexed | 2025-11-14T20:07:42Z |
| format | Article |
| id | nottingham-48048 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:07:42Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-480482024-08-15T15:29:24Z https://eprints.nottingham.ac.uk/48048/ Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) Krishnan, Kailash Beishon, Lucy Berge, Eivind Christensen, Hanne Dineen, Robert A. Ozturk, Serefnur Sprigg, Nikola Wardlow, Joanna M. Bath, Philip M.W. Background and purpose: Although poor prognosis after intracerebral haemorrhage relates to risk factors and haematoma characteristics, there is limited evidence for the effect of race-ethnicity. Methods: Data from 1011 patients with intracerebral haemorrhage enrolled into hyperacute trials and randomised to control were obtained from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke (ENOS) Trial. Clinical characteristics and functional outcome were compared among three racial groups – Asians, Blacks and Caucasians. Results: The majority of patients were Caucasian (78.1%) followed by Asians (14.5%) and Blacks (5.5%). At baseline, Caucasians were older and had larger haematoma volumes; Blacks had lower Glasgow Coma Scale and higher systolic blood pressure (all p<0.05). Although the primary outcome of modified Rankin scale (mRS) did not differ at 90 days (p=0.14), there were significant differences in mortality (p<0.0001) and quality of life (EQ-5D p<0.0001; EQ-VAS p 0.015). In test of multiple comparisons, Caucasians were more likely to die (p=0.0003) and had worse quality of life (EQ-5D p=0.003; EQ-VAS p<0.0001) as compared to Asians. Conclusion: Race-ethnicity appears to explain some of the variation in clinical characteristics and outcomes after acute intracerebral haemorrhage. Factors that explain this variation need to be identified. Wiley 2018-06-01 Article PeerReviewed Krishnan, Kailash, Beishon, Lucy, Berge, Eivind, Christensen, Hanne, Dineen, Robert A., Ozturk, Serefnur, Sprigg, Nikola, Wardlow, Joanna M. and Bath, Philip M.W. (2018) Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS). International Journal of Stroke, 13 (4). pp. 362-373. ISSN 1747-4949 intracerebral haemorrhage ethnicity race outcome randomised controlled trial http://journals.sagepub.com/doi/10.1177/1747493017744463 doi:10.1177/1747493017744463 doi:10.1177/1747493017744463 |
| spellingShingle | intracerebral haemorrhage ethnicity race outcome randomised controlled trial Krishnan, Kailash Beishon, Lucy Berge, Eivind Christensen, Hanne Dineen, Robert A. Ozturk, Serefnur Sprigg, Nikola Wardlow, Joanna M. Bath, Philip M.W. Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) |
| title | Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) |
| title_full | Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) |
| title_fullStr | Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) |
| title_full_unstemmed | Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) |
| title_short | Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) |
| title_sort | relationship between race and outcome in asian, black and caucasian patients with spontaneous intracerebral haemorrhage: data from the virtual international stroke trials archive (vista) and efficacy of nitric oxide in stroke trial (enos) |
| topic | intracerebral haemorrhage ethnicity race outcome randomised controlled trial |
| url | https://eprints.nottingham.ac.uk/48048/ https://eprints.nottingham.ac.uk/48048/ https://eprints.nottingham.ac.uk/48048/ |