Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes

Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now a well-established modality for modeling genetic disorders of the heart. This is especially so for long QT syndrome (LQTS), which is caused by perturbation of ion channel function, and can lead to fainting, malig...

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Bibliographic Details
Main Authors: Duncan, Gary, Firth, Karl S.A., George, Vinoj, Hoang, Minh Duc, Stainforth, Andrew, Smith, Godfrey, Denning, Chris
Format: Article
Published: Mary Ann Liebert 2017
Subjects:
Human induced pluripotent stem cells; Cardiomyocytes; Disease modelling; Long QT syndrome; Action 23 potentials; Electrophysiology; IKr; HERG; IKATP; PPAR delta; Ion channel drug agonists
Online Access:https://eprints.nottingham.ac.uk/48029/

Internet

https://eprints.nottingham.ac.uk/48029/

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