ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis

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ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is characterised by accumulation of extra cellular matrix (ECM) proteins and fibroblast proliferation. ECM cross-linking enzymes have been implicated in fibrotic diseases and we hypothesised that the ECM in IPF is abnormally cross-linked which enhances fibroblast...

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Bibliographic Details
Main Authors:	Philp, Christopher J., Siebeke, Ivonne, Clements, Debbie, Miller, Suzanne, Hapgood, Anthony, John, Alison E., Navaratnam, Vidya, Hubbard, Richard B., Jenkins, Gisli, Johnson, Simon R.
Format:	Article
Published:	American Thoracic Society 2017
Subjects:	IPF; Fibroblast; Extracellular Matrix Cross-linking; Transglutaminase
Online Access:	https://eprints.nottingham.ac.uk/47990/

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