Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours

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Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours

Missense somatic mutations affecting histone H3.1 and H3.3 proteins are now accepted as the hallmark of paediatric diffuse intrinsic pontine gliomas (DIPG), non-brain stem paediatric high grade gliomas (pHGG) as well as a subset of adult glioblastoma multiforme (GBM). Different mutations give rise t...

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Bibliographic Details
Main Authors:	Haque, Farhana, Varlet, Pascale, Puntonet, Julien, Storer, Lisa, Bountali, Aikaterini, Rahman, Ruman, Grill, Jacques, Carcaboso, Angel M., Jones, Chris, Layfield, Robert, Grundy, Richard G.
Format:	Article
Published:	BioMed Central 2017
Subjects:	Histone mutations ; H3 ; 3H3 ; DIPG ; pHGG ; Brain tumour
Online Access:	https://eprints.nottingham.ac.uk/47918/

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