Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation
High temperature melts or use of organic solvents are not practicable approaches for encapsulating protein based or thermally labile drugs into degradable polymers. Here, we demonstrate that poly(ethylene glycol) (PEG) in combination with supercritical carbon dioxide (scCO2) can dramatically reduce...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/47814/ |
| _version_ | 1848797635303964672 |
|---|---|
| author | Pepper, Katie Masson, Timothé De Focatiis, Davide S.A. Howdle, Steven M. |
| author_facet | Pepper, Katie Masson, Timothé De Focatiis, Davide S.A. Howdle, Steven M. |
| author_sort | Pepper, Katie |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | High temperature melts or use of organic solvents are not practicable approaches for encapsulating protein based or thermally labile drugs into degradable polymers. Here, we demonstrate that poly(ethylene glycol) (PEG) in combination with supercritical carbon dioxide (scCO2) can dramatically reduce the viscosity of polymer melts allowing enhanced uptake of CO2 into poly(D,L-lactide) (PLA). Both PEG and CO2 are approved excipients in drug delivery and it is well documented that individually both are effective plasticisers. Using high pressure rheology techniques (scCO₂ at 14 MPa) we demonstrate a synergistic impact leading to significantly lower processing temperatures with PEG employed as both a blended additive and as a component of a block copolymer. |
| first_indexed | 2025-11-14T20:07:00Z |
| format | Article |
| id | nottingham-47814 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:07:00Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-478142020-05-04T19:14:46Z https://eprints.nottingham.ac.uk/47814/ Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation Pepper, Katie Masson, Timothé De Focatiis, Davide S.A. Howdle, Steven M. High temperature melts or use of organic solvents are not practicable approaches for encapsulating protein based or thermally labile drugs into degradable polymers. Here, we demonstrate that poly(ethylene glycol) (PEG) in combination with supercritical carbon dioxide (scCO2) can dramatically reduce the viscosity of polymer melts allowing enhanced uptake of CO2 into poly(D,L-lactide) (PLA). Both PEG and CO2 are approved excipients in drug delivery and it is well documented that individually both are effective plasticisers. Using high pressure rheology techniques (scCO₂ at 14 MPa) we demonstrate a synergistic impact leading to significantly lower processing temperatures with PEG employed as both a blended additive and as a component of a block copolymer. Elsevier 2017-10-31 Article PeerReviewed Pepper, Katie, Masson, Timothé, De Focatiis, Davide S.A. and Howdle, Steven M. (2017) Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation. Journal of Supercritical Fluids, 133 (1). pp. 343-348. ISSN 1872-8162 Viscosity Rheology Polymers PLA PEG Block copolymers Blends Supercritical carbon dioxide http://www.sciencedirect.com/science/article/pii/S0896844617304631 doi:10.1016/j.supflu.2017.10.014 doi:10.1016/j.supflu.2017.10.014 |
| spellingShingle | Viscosity Rheology Polymers PLA PEG Block copolymers Blends Supercritical carbon dioxide Pepper, Katie Masson, Timothé De Focatiis, Davide S.A. Howdle, Steven M. Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation |
| title | Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation |
| title_full | Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation |
| title_fullStr | Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation |
| title_full_unstemmed | Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation |
| title_short | Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation |
| title_sort | can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? a high pressure rheology investigation |
| topic | Viscosity Rheology Polymers PLA PEG Block copolymers Blends Supercritical carbon dioxide |
| url | https://eprints.nottingham.ac.uk/47814/ https://eprints.nottingham.ac.uk/47814/ https://eprints.nottingham.ac.uk/47814/ |