Flow bioreactors as complementary tools for biocatalytic process intensification
Biocatalysis has widened its scope and relevance since new molecular tools, including improved expression systems for proteins, protein and metabolic engineering, and rational techniques for immobilization, have become available. However, applications are still sometimes hampered by low productivity...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/47805/ |
| _version_ | 1848797633574862848 |
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| author | Tamborini, Lucia Fernandes, Pedro Paradisi, Francesca Molinari, Francesco |
| author_facet | Tamborini, Lucia Fernandes, Pedro Paradisi, Francesca Molinari, Francesco |
| author_sort | Tamborini, Lucia |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Biocatalysis has widened its scope and relevance since new molecular tools, including improved expression systems for proteins, protein and metabolic engineering, and rational techniques for immobilization, have become available. However, applications are still sometimes hampered by low productivity and difficulties in scaling up. A practical and reasonable step to improve the performances of biocatalysts (including both enzymes and whole-cell systems) is to use them in flow reactors. This review describes the state of the art on the design and use of biocatalysis in flow reactors. The encouraging successes of this enabling technology are critically discussed, highlighting new opportunities, problems to be solved and technological advances. |
| first_indexed | 2025-11-14T20:06:59Z |
| format | Article |
| id | nottingham-47805 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:06:59Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-478052020-05-04T19:12:50Z https://eprints.nottingham.ac.uk/47805/ Flow bioreactors as complementary tools for biocatalytic process intensification Tamborini, Lucia Fernandes, Pedro Paradisi, Francesca Molinari, Francesco Biocatalysis has widened its scope and relevance since new molecular tools, including improved expression systems for proteins, protein and metabolic engineering, and rational techniques for immobilization, have become available. However, applications are still sometimes hampered by low productivity and difficulties in scaling up. A practical and reasonable step to improve the performances of biocatalysts (including both enzymes and whole-cell systems) is to use them in flow reactors. This review describes the state of the art on the design and use of biocatalysis in flow reactors. The encouraging successes of this enabling technology are critically discussed, highlighting new opportunities, problems to be solved and technological advances. Elsevier 2017-10-17 Article PeerReviewed Tamborini, Lucia, Fernandes, Pedro, Paradisi, Francesca and Molinari, Francesco (2017) Flow bioreactors as complementary tools for biocatalytic process intensification. Trends in Biotechnology . ISSN 0167-7799 biocatalysis ; continuous flow reactor ; process intensification ; biocatalyst immobilization http://www.sciencedirect.com/science/article/pii/S0167779917302494?via%3Dihub https://doi.org/10.1016/j.tibtech.2017.09.005 https://doi.org/10.1016/j.tibtech.2017.09.005 |
| spellingShingle | biocatalysis ; continuous flow reactor ; process intensification ; biocatalyst immobilization Tamborini, Lucia Fernandes, Pedro Paradisi, Francesca Molinari, Francesco Flow bioreactors as complementary tools for biocatalytic process intensification |
| title | Flow bioreactors as complementary tools for biocatalytic process intensification |
| title_full | Flow bioreactors as complementary tools for biocatalytic process intensification |
| title_fullStr | Flow bioreactors as complementary tools for biocatalytic process intensification |
| title_full_unstemmed | Flow bioreactors as complementary tools for biocatalytic process intensification |
| title_short | Flow bioreactors as complementary tools for biocatalytic process intensification |
| title_sort | flow bioreactors as complementary tools for biocatalytic process intensification |
| topic | biocatalysis ; continuous flow reactor ; process intensification ; biocatalyst immobilization |
| url | https://eprints.nottingham.ac.uk/47805/ https://eprints.nottingham.ac.uk/47805/ https://eprints.nottingham.ac.uk/47805/ |