Characterisation of endogenous A2A and A2B receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: evidence for an allosteric mechanism of action for the A2B-selective antagonist PSB 603

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Characterisation of endogenous A2A and A2B receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: evidence for an allosteric mechanism of action for the A2B-selective antagonist PSB 603

Endogenous adenosine A2B receptors (A2BAR) mediate cAMP accumulation in HEK 293 cells. Here we have used a biosensor to investigate the mechanism of action of the A2BAR antagonist PSB 603 in HEK 293 cells. The A2A agonist CGS 21680 elicited a small response in these cells (circa 20% of that obtained...

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Bibliographic Details
Main Authors:	Goulding, Joelle, May, Lauren T., Hill, Stephen J.
Format:	Article
Published:	Elsevier 2018
Subjects:	Adenosine receptor; Cyclic AMP; Kinetics; Allosterism; PSB 603; A2B receptor
Online Access:	https://eprints.nottingham.ac.uk/47709/

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