Transcriptional and epigenetic control of cell fate decisions in early embryos
Mammalian embryo development is characterized by regulative mechanisms of lineage segregation and cell specification. A combination of carefully orchestrated gene expression networks, signalling pathways and epigenetic marks define specific developmental stages that can now be resolved at the single...
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| Format: | Article |
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CSIRO Publishing
2017
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| Online Access: | https://eprints.nottingham.ac.uk/47675/ |
| _version_ | 1848797603391602688 |
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| author | Alberio, Ramiro |
| author_facet | Alberio, Ramiro |
| author_sort | Alberio, Ramiro |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Mammalian embryo development is characterized by regulative mechanisms of lineage segregation and cell specification. A combination of carefully orchestrated gene expression networks, signalling pathways and epigenetic marks define specific developmental stages that can now be resolved at the single-cell level. These new ways to depict developmental processes have the potential to provide answers to unresolved questions on how lineage allocation and cell fate decisions are made during embryogenesis. Over the past few years, a flurry of studies reporting detailed single-cell transcription profiles in early embryos has complemented observations acquired using live-cell imaging following gene editing techniques to manipulate specific genes. The adoption of this newly available toolkit is reshaping how researchers are designing experiments and how they view animal development. This review presents an overview of the current knowledge on lineage segregation and cell specification in mammals, and discusses some of the outstanding questions that current technological advances can help scientists address, like never before. |
| first_indexed | 2025-11-14T20:06:30Z |
| format | Article |
| id | nottingham-47675 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:06:30Z |
| publishDate | 2017 |
| publisher | CSIRO Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-476752020-05-04T19:21:04Z https://eprints.nottingham.ac.uk/47675/ Transcriptional and epigenetic control of cell fate decisions in early embryos Alberio, Ramiro Mammalian embryo development is characterized by regulative mechanisms of lineage segregation and cell specification. A combination of carefully orchestrated gene expression networks, signalling pathways and epigenetic marks define specific developmental stages that can now be resolved at the single-cell level. These new ways to depict developmental processes have the potential to provide answers to unresolved questions on how lineage allocation and cell fate decisions are made during embryogenesis. Over the past few years, a flurry of studies reporting detailed single-cell transcription profiles in early embryos has complemented observations acquired using live-cell imaging following gene editing techniques to manipulate specific genes. The adoption of this newly available toolkit is reshaping how researchers are designing experiments and how they view animal development. This review presents an overview of the current knowledge on lineage segregation and cell specification in mammals, and discusses some of the outstanding questions that current technological advances can help scientists address, like never before. CSIRO Publishing 2017-12-04 Article PeerReviewed Alberio, Ramiro (2017) Transcriptional and epigenetic control of cell fate decisions in early embryos. Reproduction, Fertility and Development, 30 (1). ISSN 1448-5990 Lineage segregation; Epigenetics; Epiblast; Stem cells; Gastrulation; Primordial germ cells http://www.publish.csiro.au/RD/RD17403 doi:10.1071/RD17403 doi:10.1071/RD17403 |
| spellingShingle | Lineage segregation; Epigenetics; Epiblast; Stem cells; Gastrulation; Primordial germ cells Alberio, Ramiro Transcriptional and epigenetic control of cell fate decisions in early embryos |
| title | Transcriptional and epigenetic control of cell fate decisions in early embryos |
| title_full | Transcriptional and epigenetic control of cell fate decisions in early embryos |
| title_fullStr | Transcriptional and epigenetic control of cell fate decisions in early embryos |
| title_full_unstemmed | Transcriptional and epigenetic control of cell fate decisions in early embryos |
| title_short | Transcriptional and epigenetic control of cell fate decisions in early embryos |
| title_sort | transcriptional and epigenetic control of cell fate decisions in early embryos |
| topic | Lineage segregation; Epigenetics; Epiblast; Stem cells; Gastrulation; Primordial germ cells |
| url | https://eprints.nottingham.ac.uk/47675/ https://eprints.nottingham.ac.uk/47675/ https://eprints.nottingham.ac.uk/47675/ |