Diabetic neuropathy: a mechanism of TRPV1 sensitisation and the treatment with Vascular Endothelial Growth Factor-A165b (VEGF-A165b)

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Diabetic neuropathy: a mechanism of TRPV1 sensitisation and the treatment with Vascular Endothelial Growth Factor-A165b (VEGF-A165b)

Diabetic neuropathy affects up to 50% of diabetic patients and commonly presents as neuropathic pain. Streptozotocin (STZ) injected type 1 diabetic rats exhibit thermal hypersensitivity and this is caused by the sensitization of transient receptor potential vanilloid 1 (TRPV1) on DRG neurons.Thermal...

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Bibliographic Details
Main Author:	Bestall, Samuel
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2017
Subjects:	diabetes neuropathic pain TRPV1 diabetic neuropathy VEGF RAGE nociceptors
Online Access:	https://eprints.nottingham.ac.uk/47650/

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