Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II)

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Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II)

A series of novel 4-isochromanone compounds bearing N-benzyl pyridinium moiety were designed and synthesized as acetylcholinesterase (AChE) inhibitors. The biological evaluation showed that most of the target compounds exhibited potent inhibitory activities against AChE. Among them, compound 1q poss...

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Bibliographic Details
Main Authors:	Wang, Jia, Wang, Chaolei, Wu, Zheng, Li, Xinnan, Xu, Shengtao, Liu, Jie, Lan, Qinying, Zhu, Zheying, Xu, Jinyi
Format:	Article
Language:	English
Published:	Wiley 2018
Subjects:	Alzheimer’s disease acetylcholinesterase inhibitors 4-isochromanone skeleton benzyl pyridine
Online Access:	https://eprints.nottingham.ac.uk/47573/

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