Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics
Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, one year survival rates are only around ~45%. Impro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
BioMed Central
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/47538/ |
| _version_ | 1848797570377187328 |
|---|---|
| author | Simpson, Siobhan Dunning, Mark D. de Brot, Simone Grau-Roma, Llorenc Mongan, Nigel P. Rutland, Catrin S. |
| author_facet | Simpson, Siobhan Dunning, Mark D. de Brot, Simone Grau-Roma, Llorenc Mongan, Nigel P. Rutland, Catrin S. |
| author_sort | Simpson, Siobhan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, one year survival rates are only around ~45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human osteosarcoma. Finally, the current position of canine osteosarcoma genetic research is discussed and areas for additional work within the canine population are identified. |
| first_indexed | 2025-11-14T20:05:59Z |
| format | Article |
| id | nottingham-47538 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:05:59Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-475382020-05-04T19:14:08Z https://eprints.nottingham.ac.uk/47538/ Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics Simpson, Siobhan Dunning, Mark D. de Brot, Simone Grau-Roma, Llorenc Mongan, Nigel P. Rutland, Catrin S. Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, one year survival rates are only around ~45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human osteosarcoma. Finally, the current position of canine osteosarcoma genetic research is discussed and areas for additional work within the canine population are identified. BioMed Central 2017-10-24 Article PeerReviewed Simpson, Siobhan, Dunning, Mark D., de Brot, Simone, Grau-Roma, Llorenc, Mongan, Nigel P. and Rutland, Catrin S. (2017) Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics. Acta Veterinaria Scandinavica, 59 . 71/1-71/11. ISSN 1751-0147 Canine; Human; Osteosarcoma; Bone cancer; Treatment; Genetics; Molecular; Diagnostics https://actavetscand.biomedcentral.com/articles/10.1186/s13028-017-0341-9 doi:10.1186/s13028-017-0341-9 doi:10.1186/s13028-017-0341-9 |
| spellingShingle | Canine; Human; Osteosarcoma; Bone cancer; Treatment; Genetics; Molecular; Diagnostics Simpson, Siobhan Dunning, Mark D. de Brot, Simone Grau-Roma, Llorenc Mongan, Nigel P. Rutland, Catrin S. Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
| title | Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
| title_full | Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
| title_fullStr | Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
| title_full_unstemmed | Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
| title_short | Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
| title_sort | comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
| topic | Canine; Human; Osteosarcoma; Bone cancer; Treatment; Genetics; Molecular; Diagnostics |
| url | https://eprints.nottingham.ac.uk/47538/ https://eprints.nottingham.ac.uk/47538/ https://eprints.nottingham.ac.uk/47538/ |