| Summary: | This thesis presents a range of novel mono and di-substituted hydroxyapatite powders, characterised by a range of techniques to ascertain their chemical composition, crystallographic composition, physical properties, and in vitro bioactivity.
The novel compositions consist of substituting a range of Borate, Sulphate, Silicate, and Strontium in levels ranging from 1.5 mol.%, up to 5 mol.%. It was found that a 4 mol.% inclusion of 2 mol.% Sr2+ and 2 mol.% SO42- gave a significant increase in the amount of osteocalcin produced and may represent an improved biomaterial warranting further study.
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