Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study
Objectives To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute attacks of gout. Methods Individuals with gout...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Public Library of Science
2017
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| Online Access: | https://eprints.nottingham.ac.uk/47474/ |
| _version_ | 1848797555995967488 |
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| author | Kunze, Gotthard Abhishek, Abhishek Valdes, Ana M. Jenkins, Wendy Zhang, Weiya Doherty, Michael |
| author_facet | Kunze, Gotthard Abhishek, Abhishek Valdes, Ana M. Jenkins, Wendy Zhang, Weiya Doherty, Michael |
| author_sort | Kunze, Gotthard |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objectives
To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute attacks of gout.
Methods
Individuals with gout were asked to fill a questionnaire enquiring about triggers that precipitated their acute gout attacks. Binary logistic regression was used to compute odds ratio (OR) and 95% confidence intervals (CI) to examine the association between having ≥1 self-reported trigger of acute gout and disease and demographic risk factors and to adjust for covariates. All statistical analyses were performed using STATA.
Results
550 participants returned completed questionnaires. 206 (37.5%) reported at least one trigger of acute attacks, and less than 5% reported >2 triggers. Only 28.73% participants reported that their most recent gout attack was triggered by dietary or lifestyle risk factors. The most frequently self-reported triggers were alcohol intake (14.18%), red-meat or sea-food consumption (6%), dehydration (4.91%), injury or excess activity (4.91%), and excessively warm or cold weather (4.36% and 5.45%). Patients who had onset of gout before the age of 50 years were significantly more likely to identify a trigger for precipitating their acute gout attacks (aOR (95%CI) 1.73 (1.12–2.68) after adjusting for covariates.
Conclusion
Most people with gout do not identify any triggers for acute attacks, and identifiable triggers are more common in those with young onset gout. Less than 20% people self-reported acute gout attacks from conventionally accepted triggers of gout e.g. alcohol, red-meat intake, while c.5% reported novel triggers such as dehydration, injury or physical activity, and weather extremes. |
| first_indexed | 2025-11-14T20:05:45Z |
| format | Article |
| id | nottingham-47474 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:05:45Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-474742020-05-04T19:12:27Z https://eprints.nottingham.ac.uk/47474/ Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study Kunze, Gotthard Abhishek, Abhishek Valdes, Ana M. Jenkins, Wendy Zhang, Weiya Doherty, Michael Objectives To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute attacks of gout. Methods Individuals with gout were asked to fill a questionnaire enquiring about triggers that precipitated their acute gout attacks. Binary logistic regression was used to compute odds ratio (OR) and 95% confidence intervals (CI) to examine the association between having ≥1 self-reported trigger of acute gout and disease and demographic risk factors and to adjust for covariates. All statistical analyses were performed using STATA. Results 550 participants returned completed questionnaires. 206 (37.5%) reported at least one trigger of acute attacks, and less than 5% reported >2 triggers. Only 28.73% participants reported that their most recent gout attack was triggered by dietary or lifestyle risk factors. The most frequently self-reported triggers were alcohol intake (14.18%), red-meat or sea-food consumption (6%), dehydration (4.91%), injury or excess activity (4.91%), and excessively warm or cold weather (4.36% and 5.45%). Patients who had onset of gout before the age of 50 years were significantly more likely to identify a trigger for precipitating their acute gout attacks (aOR (95%CI) 1.73 (1.12–2.68) after adjusting for covariates. Conclusion Most people with gout do not identify any triggers for acute attacks, and identifiable triggers are more common in those with young onset gout. Less than 20% people self-reported acute gout attacks from conventionally accepted triggers of gout e.g. alcohol, red-meat intake, while c.5% reported novel triggers such as dehydration, injury or physical activity, and weather extremes. Public Library of Science 2017-10-12 Article PeerReviewed Kunze, Gotthard, Abhishek, Abhishek, Valdes, Ana M., Jenkins, Wendy, Zhang, Weiya and Doherty, Michael (2017) Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study. PLoS ONE, 12 (10). e0186096/1-e0186096/10. ISSN 1932-6203 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186096 doi:10.1371/journal.pone.0186096 doi:10.1371/journal.pone.0186096 |
| spellingShingle | Kunze, Gotthard Abhishek, Abhishek Valdes, Ana M. Jenkins, Wendy Zhang, Weiya Doherty, Michael Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study |
| title | Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study |
| title_full | Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study |
| title_fullStr | Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study |
| title_full_unstemmed | Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study |
| title_short | Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study |
| title_sort | triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study |
| url | https://eprints.nottingham.ac.uk/47474/ https://eprints.nottingham.ac.uk/47474/ https://eprints.nottingham.ac.uk/47474/ |