Establishment of the human cardiac models using gene editing and reprogramming in Human Pluripotent Stem Cells to understand the putative functions of the G-protein coupled receptor kinase 5 polymorphism (GRK5-L41)

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Establishment of the human cardiac models using gene editing and reprogramming in Human Pluripotent Stem Cells to understand the putative functions of the G-protein coupled receptor kinase 5 polymorphism (GRK5-L41)

A nonsynonymous single polymorphism (SNP) in G protein-coupled receptor kinase 5 (GRK5) was discovered in 2008 that changes the amino acid at the position 41 from Glutamine (Q) into Leucine (L) (Liggett et al., 2008). The putative functions of the GRK5-L41 polymorphism were reported to be involved i...

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Bibliographic Details
Main Author:	Hoang, Minh Duc
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2017
Subjects:	GRK5-L41 polymorphism; G proteins; Pluripotent Stem Cells; Heart cells; Cardiac model
Online Access:	https://eprints.nottingham.ac.uk/47429/

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