Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions
BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesions, it has not been fully optimized for visualizat...
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SAGE Publications
2017
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| Online Access: | https://eprints.nottingham.ac.uk/47411/ |
| _version_ | 1848797539784982528 |
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| author | Chou, I-Jun Lim, Su-Yin Tanasescu, Radu Al-Radaideh, Ali Mougin, Olivier E. Tench, Christopher R. Whitehouse, William P. Gowland, Penny A. Constantinescu, Cris S. |
| author_facet | Chou, I-Jun Lim, Su-Yin Tanasescu, Radu Al-Radaideh, Ali Mougin, Olivier E. Tench, Christopher R. Whitehouse, William P. Gowland, Penny A. Constantinescu, Cris S. |
| author_sort | Chou, I-Jun |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesions, it has not been fully optimized for visualization of white matter lesions and thus has not been used for delineating lesions in quantitative magnetic resonance imaging (MRI) studies of the normal appearing white matter in multiple sclerosis. Therefore, we aimed to evaluate the sensitivity of 7T magnetization-transfer-weighted (MTw) images in the detection of white matter lesions compared with 3T-FLAIR.
METHODS:Fifteen patients with clinically isolated syndrome, 6 with multiple sclerosis, and 10 healthy participants were scanned with 7T 3-dimensional (D) MTw and 3T-2D-FLAIR sequences on the same day. White matter lesions visible on either sequence were delineated.
RESULTS: Of 662 lesions identified on 3T-2D-FLAIR images, 652 were detected on 7T-3D-MTw images (sensitivity, 98%; 95% confidence interval, 97% to 99%). The Spearman correlation coefficient between lesion loads estimated by the two sequences was .910. The intrarater and interrater reliability for 7T-3D-MTw images was good with an intraclass correlation coefficient (ICC) of 98.4% and 81.8%, which is similar to that for 3T-2D-FLAIR images (ICC 96.1% and 96.7%).
CONCLUSION: Seven-Tesla MTw sequences detected most of the white matter lesions identified by FLAIR at 3T. This suggests that 7T-MTw imaging is a robust alternative for detecting demyelinating lesions in addition to 3T-FLAIR. Future studies need to compare the roles of optimized 7T-FLAIR and of 7T-MTw imaging. |
| first_indexed | 2025-11-14T20:05:29Z |
| format | Article |
| id | nottingham-47411 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:05:29Z |
| publishDate | 2017 |
| publisher | SAGE Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-474112020-05-04T19:08:26Z https://eprints.nottingham.ac.uk/47411/ Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions Chou, I-Jun Lim, Su-Yin Tanasescu, Radu Al-Radaideh, Ali Mougin, Olivier E. Tench, Christopher R. Whitehouse, William P. Gowland, Penny A. Constantinescu, Cris S. BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesions, it has not been fully optimized for visualization of white matter lesions and thus has not been used for delineating lesions in quantitative magnetic resonance imaging (MRI) studies of the normal appearing white matter in multiple sclerosis. Therefore, we aimed to evaluate the sensitivity of 7T magnetization-transfer-weighted (MTw) images in the detection of white matter lesions compared with 3T-FLAIR. METHODS:Fifteen patients with clinically isolated syndrome, 6 with multiple sclerosis, and 10 healthy participants were scanned with 7T 3-dimensional (D) MTw and 3T-2D-FLAIR sequences on the same day. White matter lesions visible on either sequence were delineated. RESULTS: Of 662 lesions identified on 3T-2D-FLAIR images, 652 were detected on 7T-3D-MTw images (sensitivity, 98%; 95% confidence interval, 97% to 99%). The Spearman correlation coefficient between lesion loads estimated by the two sequences was .910. The intrarater and interrater reliability for 7T-3D-MTw images was good with an intraclass correlation coefficient (ICC) of 98.4% and 81.8%, which is similar to that for 3T-2D-FLAIR images (ICC 96.1% and 96.7%). CONCLUSION: Seven-Tesla MTw sequences detected most of the white matter lesions identified by FLAIR at 3T. This suggests that 7T-MTw imaging is a robust alternative for detecting demyelinating lesions in addition to 3T-FLAIR. Future studies need to compare the roles of optimized 7T-FLAIR and of 7T-MTw imaging. SAGE Publications 2017-09-25 Article PeerReviewed Chou, I-Jun, Lim, Su-Yin, Tanasescu, Radu, Al-Radaideh, Ali, Mougin, Olivier E., Tench, Christopher R., Whitehouse, William P., Gowland, Penny A. and Constantinescu, Cris S. (2017) Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions. Journal of Neuroimaging . ISSN 1051-2284 Demyelination FLAIR magnetization transfer-saturated sequence multiple sclerosis http://onlinelibrary.wiley.com/doi/10.1111/jon.12474/abstract doi:10.1111/jon.12474 doi:10.1111/jon.12474 |
| spellingShingle | Demyelination FLAIR magnetization transfer-saturated sequence multiple sclerosis Chou, I-Jun Lim, Su-Yin Tanasescu, Radu Al-Radaideh, Ali Mougin, Olivier E. Tench, Christopher R. Whitehouse, William P. Gowland, Penny A. Constantinescu, Cris S. Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions |
| title | Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions |
| title_full | Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions |
| title_fullStr | Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions |
| title_full_unstemmed | Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions |
| title_short | Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions |
| title_sort | seven-tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions |
| topic | Demyelination FLAIR magnetization transfer-saturated sequence multiple sclerosis |
| url | https://eprints.nottingham.ac.uk/47411/ https://eprints.nottingham.ac.uk/47411/ https://eprints.nottingham.ac.uk/47411/ |