Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative
Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical applica...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Wiley
2018
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| Online Access: | https://eprints.nottingham.ac.uk/47409/ |
| _version_ | 1848797539167371264 |
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| author | Kottner, Jan Jacobi, Lena Hahnel, Elisabeth Alam, Murad Beeckman, Dimitri Busard, Celine Chalmers, J.R. Deckert, Stefanie Eleftheriadou, Viktoria Furlan, Karina Horbach, Sophie E.R. Kirkham, Jamie J. Nast, Alexander Thiboutot, Diane Thorlacius, Linnea Weller, Karsten Williams, Hywel C. Schmitt, Jochen |
| author_facet | Kottner, Jan Jacobi, Lena Hahnel, Elisabeth Alam, Murad Beeckman, Dimitri Busard, Celine Chalmers, J.R. Deckert, Stefanie Eleftheriadou, Viktoria Furlan, Karina Horbach, Sophie E.R. Kirkham, Jamie J. Nast, Alexander Thiboutot, Diane Thorlacius, Linnea Weller, Karsten Williams, Hywel C. Schmitt, Jochen |
| author_sort | Kottner, Jan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COSs) aim to overcome this limitation. A COS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG-COUSIN) supports the development of core outcomes in dermatology.
In the second CSG-COUSIN meeting held in 2017, 11 COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges for COS development in dermatology: it is not always easy to define the disease focus of a COS; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers and COS developers. |
| first_indexed | 2025-11-14T20:05:29Z |
| format | Article |
| id | nottingham-47409 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:05:29Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-474092020-05-04T19:51:54Z https://eprints.nottingham.ac.uk/47409/ Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative Kottner, Jan Jacobi, Lena Hahnel, Elisabeth Alam, Murad Beeckman, Dimitri Busard, Celine Chalmers, J.R. Deckert, Stefanie Eleftheriadou, Viktoria Furlan, Karina Horbach, Sophie E.R. Kirkham, Jamie J. Nast, Alexander Thiboutot, Diane Thorlacius, Linnea Weller, Karsten Williams, Hywel C. Schmitt, Jochen Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COSs) aim to overcome this limitation. A COS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG-COUSIN) supports the development of core outcomes in dermatology. In the second CSG-COUSIN meeting held in 2017, 11 COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges for COS development in dermatology: it is not always easy to define the disease focus of a COS; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers and COS developers. Wiley 2018-04 Article PeerReviewed Kottner, Jan, Jacobi, Lena, Hahnel, Elisabeth, Alam, Murad, Beeckman, Dimitri, Busard, Celine, Chalmers, J.R., Deckert, Stefanie, Eleftheriadou, Viktoria, Furlan, Karina, Horbach, Sophie E.R., Kirkham, Jamie J., Nast, Alexander, Thiboutot, Diane, Thorlacius, Linnea, Weller, Karsten, Williams, Hywel C. and Schmitt, Jochen (2018) Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative. British Journal of Dermatology, 178 (4). e279-e285. ISSN 1365-2133 http://onlinelibrary.wiley.com/doi/10.1111/bjd.16324/abstract doi:10.1111/bjd.16324 doi:10.1111/bjd.16324 |
| spellingShingle | Kottner, Jan Jacobi, Lena Hahnel, Elisabeth Alam, Murad Beeckman, Dimitri Busard, Celine Chalmers, J.R. Deckert, Stefanie Eleftheriadou, Viktoria Furlan, Karina Horbach, Sophie E.R. Kirkham, Jamie J. Nast, Alexander Thiboutot, Diane Thorlacius, Linnea Weller, Karsten Williams, Hywel C. Schmitt, Jochen Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative |
| title | Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative |
| title_full | Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative |
| title_fullStr | Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative |
| title_full_unstemmed | Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative |
| title_short | Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative |
| title_sort | core outcome sets in dermatology: report from the second meeting of the international cochrane skin group core outcome set initiative |
| url | https://eprints.nottingham.ac.uk/47409/ https://eprints.nottingham.ac.uk/47409/ https://eprints.nottingham.ac.uk/47409/ |