IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review
Bullous Pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesio...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Springer
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/47405/ |
| _version_ | 1848797537936343040 |
|---|---|
| author | Hadjikyriacou Saniklidou, Ariadne Tighe, Patrick J. Fairclough, Lucy C. Todd, Ian |
| author_facet | Hadjikyriacou Saniklidou, Ariadne Tighe, Patrick J. Fairclough, Lucy C. Todd, Ian |
| author_sort | Hadjikyriacou Saniklidou, Ariadne |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Bullous Pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesion molecule between the epidermis and the basement membrane of the dermis. About 40 years ago, following consistent findings of elevated total serum IgE levels in BP patients, it was hypothesized that IgE may be involved in the pathophysiology of BP. Our objective was to determine whether there is strong evidence for an association between IgE class autoantibodies and the clinical severity or phenotype of BP. Three databases were searched for relevant studies and appropriate exclusion and inclusion criteria were applied. Data was extracted and assessed in relation to the study questions concerning the clinical significance of IgE autoantibodies in BP. Nine studies found that anti-BP180 autoantibodies of IgE class are associated with increased severity of BP, whereas two studies did not find such an association. The number of studies which found an association between higher IgE autoantibody levels and the erythematous urticarial phenotype of BP (5) were equal in number to the studies which found no such association (5). In conclusion, higher serum IgE autoantibody levels are associated with more severe clinical manifestations of BP. There is insufficient evidence to support higher IgE autoantibody levels being associated with specific clinical phenotypes of BP. |
| first_indexed | 2025-11-14T20:05:28Z |
| format | Article |
| id | nottingham-47405 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:05:28Z |
| publishDate | 2017 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-474052020-05-04T19:13:50Z https://eprints.nottingham.ac.uk/47405/ IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review Hadjikyriacou Saniklidou, Ariadne Tighe, Patrick J. Fairclough, Lucy C. Todd, Ian Bullous Pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesion molecule between the epidermis and the basement membrane of the dermis. About 40 years ago, following consistent findings of elevated total serum IgE levels in BP patients, it was hypothesized that IgE may be involved in the pathophysiology of BP. Our objective was to determine whether there is strong evidence for an association between IgE class autoantibodies and the clinical severity or phenotype of BP. Three databases were searched for relevant studies and appropriate exclusion and inclusion criteria were applied. Data was extracted and assessed in relation to the study questions concerning the clinical significance of IgE autoantibodies in BP. Nine studies found that anti-BP180 autoantibodies of IgE class are associated with increased severity of BP, whereas two studies did not find such an association. The number of studies which found an association between higher IgE autoantibody levels and the erythematous urticarial phenotype of BP (5) were equal in number to the studies which found no such association (5). In conclusion, higher serum IgE autoantibody levels are associated with more severe clinical manifestations of BP. There is insufficient evidence to support higher IgE autoantibody levels being associated with specific clinical phenotypes of BP. Springer 2017-10-25 Article PeerReviewed Hadjikyriacou Saniklidou, Ariadne, Tighe, Patrick J., Fairclough, Lucy C. and Todd, Ian (2017) IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review. Archives of Dermatological Research, 310 (1). pp. 11-28. ISSN 1432-069X Bullous Pemphigoid; BP; Immunoglobulin E; IgE; Autoantibodies; Disease severity; Disease activity; Disease course; Clinical phenotype; Clinical manifestations https://link.springer.com/article/10.1007/s00403-017-1789-1 doi:10.1007/s00403-017-1789-1 doi:10.1007/s00403-017-1789-1 |
| spellingShingle | Bullous Pemphigoid; BP; Immunoglobulin E; IgE; Autoantibodies; Disease severity; Disease activity; Disease course; Clinical phenotype; Clinical manifestations Hadjikyriacou Saniklidou, Ariadne Tighe, Patrick J. Fairclough, Lucy C. Todd, Ian IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review |
| title | IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review |
| title_full | IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review |
| title_fullStr | IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review |
| title_full_unstemmed | IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review |
| title_short | IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review |
| title_sort | ige autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review |
| topic | Bullous Pemphigoid; BP; Immunoglobulin E; IgE; Autoantibodies; Disease severity; Disease activity; Disease course; Clinical phenotype; Clinical manifestations |
| url | https://eprints.nottingham.ac.uk/47405/ https://eprints.nottingham.ac.uk/47405/ https://eprints.nottingham.ac.uk/47405/ |