Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports
In this clinical study, for the first time we used the direct gene therapy to restore severe injuries of the suspensory ligament branch and superficial digital flexor tendon in horses (Equus caballus). We injected the plasmid DNA encoding two therapeutic species-specific growth factors: vascular end...
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Frontiers
2017
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| Online Access: | https://eprints.nottingham.ac.uk/47109/ |
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| author | Kovac, Milomir Litvin, Yaroslav A. Aliev, Ruslan O. Zakirova, Elena Yu Rutland, Catrin S. Kiyasov, Andrey Rizvanov, Albert A. |
| author_facet | Kovac, Milomir Litvin, Yaroslav A. Aliev, Ruslan O. Zakirova, Elena Yu Rutland, Catrin S. Kiyasov, Andrey Rizvanov, Albert A. |
| author_sort | Kovac, Milomir |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In this clinical study, for the first time we used the direct gene therapy to restore severe injuries of the suspensory ligament branch and superficial digital flexor tendon in horses (Equus caballus). We injected the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor 164 and fibroblast growth factor 2 at the site of injury in the suspensory ligament branch and tendon. Treatment effects were evaluated with the use of clinical observation and ultrasound imaging during a period of a few months. We showed that gene therapy used within a period of 2–3 months after the injury resulted in the complete recovery of functions and full restoration of the severely damaged suspensory ligament and superficial digital flexor tendon. |
| first_indexed | 2025-11-14T20:04:22Z |
| format | Article |
| id | nottingham-47109 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:04:22Z |
| publishDate | 2017 |
| publisher | Frontiers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-471092020-05-04T19:12:11Z https://eprints.nottingham.ac.uk/47109/ Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports Kovac, Milomir Litvin, Yaroslav A. Aliev, Ruslan O. Zakirova, Elena Yu Rutland, Catrin S. Kiyasov, Andrey Rizvanov, Albert A. In this clinical study, for the first time we used the direct gene therapy to restore severe injuries of the suspensory ligament branch and superficial digital flexor tendon in horses (Equus caballus). We injected the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor 164 and fibroblast growth factor 2 at the site of injury in the suspensory ligament branch and tendon. Treatment effects were evaluated with the use of clinical observation and ultrasound imaging during a period of a few months. We showed that gene therapy used within a period of 2–3 months after the injury resulted in the complete recovery of functions and full restoration of the severely damaged suspensory ligament and superficial digital flexor tendon. Frontiers 2017-10-10 Article PeerReviewed Kovac, Milomir, Litvin, Yaroslav A., Aliev, Ruslan O., Zakirova, Elena Yu, Rutland, Catrin S., Kiyasov, Andrey and Rizvanov, Albert A. (2017) Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports. Frontiers in Veterinary Science, 4 (168). pp. 1-6. ISSN 2297-1769 Gene therapy Tendon Suspensory ligament Horse Vascular endothelial growth factor Fibroblast growth factor https://www.frontiersin.org/articles/10.3389/fvets.2017.00168/full doi:10.3389/fvets.2017.00168 doi:10.3389/fvets.2017.00168 |
| spellingShingle | Gene therapy Tendon Suspensory ligament Horse Vascular endothelial growth factor Fibroblast growth factor Kovac, Milomir Litvin, Yaroslav A. Aliev, Ruslan O. Zakirova, Elena Yu Rutland, Catrin S. Kiyasov, Andrey Rizvanov, Albert A. Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports |
| title | Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports |
| title_full | Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports |
| title_fullStr | Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports |
| title_full_unstemmed | Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports |
| title_short | Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports |
| title_sort | gene therapy using plasmid dna encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports |
| topic | Gene therapy Tendon Suspensory ligament Horse Vascular endothelial growth factor Fibroblast growth factor |
| url | https://eprints.nottingham.ac.uk/47109/ https://eprints.nottingham.ac.uk/47109/ https://eprints.nottingham.ac.uk/47109/ |