Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line

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Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line

During the first trimester, normal placental development occurs in a low oxygen environment that is known to stimulate angiogenesis via upregulation of vascular endothelial growth factor (VEGF). Expression of the placental renin-angiotensin system (RAS) is highest in early pregnancy. While the RAS a...

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Bibliographic Details
Main Authors:	Delforce, Sarah J., Wang, Yu, Van-Aalst, Meg E., Corbisier de Meaultsart, Celine, Morris, Brian J., Broughton Pipkin, Fiona, Roberts, Claire T., Lumbers, Eugenie R., Pringle, Kirsty G.
Format:	Article
Published:	Elsevier 2016
Subjects:	Renineangiotensin system ; Pregnancy ; Placenta ; Hypoxia ; Gene expression
Online Access:	https://eprints.nottingham.ac.uk/47007/

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