Tuneable 3D printed bioreactors for transaminations under continuous-flow

A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Application of these chemically modified devices enables rapid screening of immobilization mechanisms and reaction conditions, simple transfer of optimised conditions into tailored printed microfluidic rea...

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Main Authors: Peris, Edgar, Okafor, Obinna, Kulchinskaja, Evelina, Goodridge, Ruth D., Luis, Santiago V., Garcia-Verdugo, Eduardo, O'Reilly, Elaine, Sans, Victor
Format: Article
Published: Royal Society of Chemistry 2017
Online Access:https://eprints.nottingham.ac.uk/46977/
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author Peris, Edgar
Okafor, Obinna
Kulchinskaja, Evelina
Goodridge, Ruth D.
Luis, Santiago V.
Garcia-Verdugo, Eduardo
O'Reilly, Elaine
Sans, Victor
author_facet Peris, Edgar
Okafor, Obinna
Kulchinskaja, Evelina
Goodridge, Ruth D.
Luis, Santiago V.
Garcia-Verdugo, Eduardo
O'Reilly, Elaine
Sans, Victor
author_sort Peris, Edgar
building Nottingham Research Data Repository
collection Online Access
description A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Application of these chemically modified devices enables rapid screening of immobilization mechanisms and reaction conditions, simple transfer of optimised conditions into tailored printed microfluidic reactors and development of continuous-flow biocatalytic processes. The bioreactors showed good activity (8-20.5 μmol h⁻¹ mgenz⁻¹) in the kinetic resolution of 1-methylbenzylamine, and very good stability (ca. 100 h under flow).
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institution University of Nottingham Malaysia Campus
institution_category Local University
last_indexed 2025-11-14T20:03:55Z
publishDate 2017
publisher Royal Society of Chemistry
recordtype eprints
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spelling nottingham-469772020-05-04T19:19:10Z https://eprints.nottingham.ac.uk/46977/ Tuneable 3D printed bioreactors for transaminations under continuous-flow Peris, Edgar Okafor, Obinna Kulchinskaja, Evelina Goodridge, Ruth D. Luis, Santiago V. Garcia-Verdugo, Eduardo O'Reilly, Elaine Sans, Victor A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Application of these chemically modified devices enables rapid screening of immobilization mechanisms and reaction conditions, simple transfer of optimised conditions into tailored printed microfluidic reactors and development of continuous-flow biocatalytic processes. The bioreactors showed good activity (8-20.5 μmol h⁻¹ mgenz⁻¹) in the kinetic resolution of 1-methylbenzylamine, and very good stability (ca. 100 h under flow). Royal Society of Chemistry 2017-11-21 Article PeerReviewed Peris, Edgar, Okafor, Obinna, Kulchinskaja, Evelina, Goodridge, Ruth D., Luis, Santiago V., Garcia-Verdugo, Eduardo, O'Reilly, Elaine and Sans, Victor (2017) Tuneable 3D printed bioreactors for transaminations under continuous-flow. Green Chemistry, 19 (22). pp. 5345-5349. ISSN 1463-9270 http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC02421E#!divAbstract doi:10.1039/C7GC02421E doi:10.1039/C7GC02421E
spellingShingle Peris, Edgar
Okafor, Obinna
Kulchinskaja, Evelina
Goodridge, Ruth D.
Luis, Santiago V.
Garcia-Verdugo, Eduardo
O'Reilly, Elaine
Sans, Victor
Tuneable 3D printed bioreactors for transaminations under continuous-flow
title Tuneable 3D printed bioreactors for transaminations under continuous-flow
title_full Tuneable 3D printed bioreactors for transaminations under continuous-flow
title_fullStr Tuneable 3D printed bioreactors for transaminations under continuous-flow
title_full_unstemmed Tuneable 3D printed bioreactors for transaminations under continuous-flow
title_short Tuneable 3D printed bioreactors for transaminations under continuous-flow
title_sort tuneable 3d printed bioreactors for transaminations under continuous-flow
url https://eprints.nottingham.ac.uk/46977/
https://eprints.nottingham.ac.uk/46977/
https://eprints.nottingham.ac.uk/46977/