How have retrovirus pseudotypes contributed to our understanding of viral entry?
Study of virus entry into host cells is important for understanding viral tropism and pathogenesis. Studying the entry of in vitro cultured viruses is not always practicable. Study of highly pathogenic viruses, viruses that do not grow in culture, and viruses that rapidly change phenotype in vitro c...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Published: |
Future Medicine
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/46903/ |
| _version_ | 1848797423525167104 |
|---|---|
| author | Tarr, Alexander W. King, Barnabas |
| author_facet | Tarr, Alexander W. King, Barnabas |
| author_sort | Tarr, Alexander W. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Study of virus entry into host cells is important for understanding viral tropism and pathogenesis. Studying the entry of in vitro cultured viruses is not always practicable. Study of highly pathogenic viruses, viruses that do not grow in culture, and viruses that rapidly change phenotype in vitro can all benefit from alternative models of entry. Retrovirus particles can be engineered to display the envelope proteins of heterologous enveloped viruses. This approach, broadly termed ‘pseudotyping’, is an important technique for interrogating virus entry. In this perspective we consider how retrovirus pseudotypes have addressed these challenges and improved our understanding of the entry pathways of diverse virus species, including Ebolavirus, human immunodeficiency virus and hepatitis C virus. |
| first_indexed | 2025-11-14T20:03:39Z |
| format | Article |
| id | nottingham-46903 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:03:39Z |
| publishDate | 2017 |
| publisher | Future Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-469032020-05-04T18:55:46Z https://eprints.nottingham.ac.uk/46903/ How have retrovirus pseudotypes contributed to our understanding of viral entry? Tarr, Alexander W. King, Barnabas Study of virus entry into host cells is important for understanding viral tropism and pathogenesis. Studying the entry of in vitro cultured viruses is not always practicable. Study of highly pathogenic viruses, viruses that do not grow in culture, and viruses that rapidly change phenotype in vitro can all benefit from alternative models of entry. Retrovirus particles can be engineered to display the envelope proteins of heterologous enveloped viruses. This approach, broadly termed ‘pseudotyping’, is an important technique for interrogating virus entry. In this perspective we consider how retrovirus pseudotypes have addressed these challenges and improved our understanding of the entry pathways of diverse virus species, including Ebolavirus, human immunodeficiency virus and hepatitis C virus. Future Medicine 2017-07-17 Article PeerReviewed Tarr, Alexander W. and King, Barnabas (2017) How have retrovirus pseudotypes contributed to our understanding of viral entry? Future Virology . ISSN 1746-0808 (In Press) Pseudotype Pseudoparticle Entry pathway |
| spellingShingle | Pseudotype Pseudoparticle Entry pathway Tarr, Alexander W. King, Barnabas How have retrovirus pseudotypes contributed to our understanding of viral entry? |
| title | How have retrovirus pseudotypes contributed to our understanding of viral entry? |
| title_full | How have retrovirus pseudotypes contributed to our understanding of viral entry? |
| title_fullStr | How have retrovirus pseudotypes contributed to our understanding of viral entry? |
| title_full_unstemmed | How have retrovirus pseudotypes contributed to our understanding of viral entry? |
| title_short | How have retrovirus pseudotypes contributed to our understanding of viral entry? |
| title_sort | how have retrovirus pseudotypes contributed to our understanding of viral entry? |
| topic | Pseudotype Pseudoparticle Entry pathway |
| url | https://eprints.nottingham.ac.uk/46903/ |