Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies

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Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies

Background and purpose: We evaluated the concordance of results from two sets of nonclinical cardiovascular safety studies on pitolisant. Experimental approach: Nonclinical studies envisaged both in the ICH S7B guideline and Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative were undertak...

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Bibliographic Details
Main Authors:	Ligneau, Xavier, Shah, Rashmi R., Berrebi-Bertrand, Isabelle, Mirams, Gary R., Robert, Philippe, Landais, Laurent, Maison-Blanche, Pierre, Faivre, Jean-François, Lecomte, Jeanne-Marie, Schwartz, Jean-Charles
Format:	Article
Published:	Wiley 2017
Online Access:	https://eprints.nottingham.ac.uk/46862/

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