From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor

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From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor

The G protein-coupled P2Y2 receptor, activated by ATP and UTP has been reported as a potential drug target for a wide range of important clinical conditions, such as tumor metastasis, kidney disorders, and in the treatment of inflammatory conditions. However, pharmacological studies on this receptor...

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Bibliographic Details
Main Authors:	Kindon, Nicholas, Davis, Andrew, Dougall, Iain, Dixon, John, Johnson, Timothy, Walters, Iain, Thom, Steve, McKechnie, Kenneth, Meghani, Premji, Stocks, Michael
Format:	Article
Published:	Elsevier 2017
Subjects:	P2Y2; Purinergic; AR-C118925; P2; Antagonist
Online Access:	https://eprints.nottingham.ac.uk/46762/

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