Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.

Bibliographic Details
Main Authors: Rawling, M.J., Storr, T.E., Bawazir, W.A., Cully, S.J., Lewis, W., Makki, M.S.I.T., Strutt, I.R., Jones, G., Hamza, D., Stockman, R.A.
Format: Article
Published: Royal Society of Chemistry 2015
Online Access:https://eprints.nottingham.ac.uk/46643/

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