Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy
A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Published: |
Royal Society of Chemistry
2015
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| Online Access: | https://eprints.nottingham.ac.uk/46643/ |
| _version_ | 1848797375788744704 |
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| author | Rawling, M.J. Storr, T.E. Bawazir, W.A. Cully, S.J. Lewis, W. Makki, M.S.I.T. Strutt, I.R. Jones, G. Hamza, D. Stockman, R.A. |
| author_facet | Rawling, M.J. Storr, T.E. Bawazir, W.A. Cully, S.J. Lewis, W. Makki, M.S.I.T. Strutt, I.R. Jones, G. Hamza, D. Stockman, R.A. |
| author_sort | Rawling, M.J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced. |
| first_indexed | 2025-11-14T20:02:53Z |
| format | Article |
| id | nottingham-46643 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:02:53Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-466432020-05-04T17:13:28Z https://eprints.nottingham.ac.uk/46643/ Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy Rawling, M.J. Storr, T.E. Bawazir, W.A. Cully, S.J. Lewis, W. Makki, M.S.I.T. Strutt, I.R. Jones, G. Hamza, D. Stockman, R.A. A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced. Royal Society of Chemistry 2015-07-09 Article PeerReviewed Rawling, M.J., Storr, T.E., Bawazir, W.A., Cully, S.J., Lewis, W., Makki, M.S.I.T., Strutt, I.R., Jones, G., Hamza, D. and Stockman, R.A. (2015) Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy. Chemical Communications, 51 (64). pp. 12867-12870. ISSN 1364-548X http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC05070G#!divAbstract doi:10.1039/c5cc05070g doi:10.1039/c5cc05070g |
| spellingShingle | Rawling, M.J. Storr, T.E. Bawazir, W.A. Cully, S.J. Lewis, W. Makki, M.S.I.T. Strutt, I.R. Jones, G. Hamza, D. Stockman, R.A. Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy |
| title | Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy |
| title_full | Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy |
| title_fullStr | Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy |
| title_full_unstemmed | Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy |
| title_short | Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy |
| title_sort | facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy |
| url | https://eprints.nottingham.ac.uk/46643/ https://eprints.nottingham.ac.uk/46643/ https://eprints.nottingham.ac.uk/46643/ |