Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library

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Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library

The application of a tandem condensation/cyclisation/[3+2]-cycloaddition/elimination reaction gives an sp3-rich tricyclic pyrazoline scaffold with two ethyl esters in a single step from a simple linear starting material. The successive hydrolysis and cyclisation (with Boc anhydride) of these 3-dimen...

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Bibliographic Details
Main Authors:	Storr, Thomas E., Cully, Sarah J., Rawling, Michael J., Lewis, William, Hamza, Daniel, Jones, Geraint, Stockman, Robert A.
Format:	Article
Published:	Elsevier 2015
Subjects:	sp3-rich; Natural product-like; Scaffold; Cycloaddition; Two-directional; Macrocycle; Library; Tandem
Online Access:	https://eprints.nottingham.ac.uk/46642/

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