Total synthesis of the post-translationally modified polyazole peptide antibiotic goadsporin

QR Code

Total synthesis of the post-translationally modified polyazole peptide antibiotic goadsporin

The structurally unique polyazole antibiotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear array of amino acids that also contains two dehydroalanine residues. An efficient total synthesis of goadsporin is reported in which the key steps are the use of rh...

Full description

Bibliographic Details
Main Authors:	Dexter, Hannah L., Williams, Huw E.L., Lewis, William, Moody, Christopher J.
Format:	Article
Published:	Wiley-VCH Verlag 2017
Subjects:	antibiotics; diazo compounds; heterocycles; peptides; total synthesis
Online Access:	https://eprints.nottingham.ac.uk/46635/

Similar Items

Total synthesis of the post-translationally modified polyazole peptide antibiotic plantazolicin A
by: Wada, Hiroki, et al.
Published: (2015)

Stereoselective synthesis of functionalized pyrrolidines by the diverted NH insertion reaction of metallocarbenes with β-aminoketone derivatives
by: Nicolle, Simon M., et al.
Published: (2016)

Synthesis, characterization and biological activity of new symmetrical 1,3-benzoxazine compounds
by: Hassan, Chiya Othman
Published: (2017)

Applications of catalytic C-N bond formation from diazo compounds
by: Douglas, Timothy
Published: (2019)

Towards biologically active heterocycles from renewable aromatic starting materials
by: Anderson, Edward
Published: (2019)

C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery
by: Nicolle, Simon M., et al.
Published: (2017)

Towards an Understanding of the Role of VGF-Derived Peptides
by: Ashford, Toni Winona Marie
Published: (2021)

Design, synthesis, and biochemical assay of peptide inhibitors derived from α-enolase for use against peptidylarginine deiminase type 4
by: Ahmad Nadzirin, Izzuddin
Published: (2013)

Dimerization as a strategy to engineer antimicrobial peptides for application against enteric bacterial pathogens of poultry
by: Pitchers, Kieran
Published: (2022)

Voltammetric studies of lead (ll), cadmium(ll), copper(ll) and chromium(lll) ions in the presence of selected n-heterocyclic compound
by: Rahman, Nurul Hudah
Published: (2011)

Identification And Characterization Of A Novel Anti-Viral Peptide Against Avian Influenza Virus H9n2
by: Rajik, Mohamed
Published: (2009)

Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds
by: Day, Jonathan, et al.
Published: (2016)

The development of novel antimicrobial peptides with activity against MRSA
by: Pritchard, Kevin
Published: (2008)

Characterization of peptides and proteins from epidermal mucus of climbing perch Anabas testudineus (Bloch, 1972) with antibacterial and immunomodulatory properties
by: Hussein, Agharid Ali
Published: (2018)

Copper-peptides mimicking catalytic activity of laccase in oxidation reactions
by: Begum, Sharifa Zaithun
Published: (2020)

Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds
by: Moody, Christopher J., et al.
Published: (2018)

New found hope for antibiotic discovery: lipid II inhibitors
by: Ng, Vivian, et al.
Published: (2016)

Development of a Deoxygenative Ring Contraction Reaction for Nitrogen Heterocycle Synthesis
by: Atkinson, Nick
Published: (2023)

Effect Of Cooking Methods And Conditions On Heterocyclic Amines Content In Satay And Roasted Marinated Chicken
by: Mohd Mukhtar, Mohd Safzan
Published: (2009)

Evaluation of local spices and herbs as marinating ingredients for the reduction of heterocyclic amines in grilled beef
by: Sepahpour, Shabnam
Published: (2017)

Nitrogen-Bridged, Natural Product-Like Octahydrobenzofurans and Octahydroindoles: Scope and Mechanism of Bridge-Forming Reductive Amination via Caged Heteroadamantanes
by: Wales, Steven M., et al.
Published: (2018)

Investigating agr Quorum Sensing and Autoinducing Peptide Biosynthesis in Staphylococcus aureus
by: Blower, Isobel
Published: (2023)

Characterisation of a Novel Producer, the Antimicrobial Properties and the Molecular Target of Zelkovamycin
by: Tarantini, Francesco Saverio
Published: (2020)

Microneedle Enhanced Delivery of Cosmeceutically Relevant Peptides in Human Skin
by: Mohammed, Yousuf, et al.
Published: (2014)

Molecular Editing of Indoles via Formal N-Atom Insertion and C–S Cross-Coupling in Micellar Solution
by: Valentine, Gemma
Published: (2023)

Photocatalytic Tryptophan Alkylation for Chemoselective Peptide Modification
by: Lee, Joanna
Published: (2024)

Synthesis and characterization of novel palmitic acid conjugated tetrapeptide as a new active molecule for wound treatment
by: Md Fadilah, Nur Izzah
Published: (2020)

Solution phase synthesis and characterization of peptidyl chemosensors for Pb (ll) and As (lll) detection
by: Abdull Manap, Mohd Rashidi
Published: (2012)

Domain swapping to generate new antibiotic proteins
by: Kapp, James
Published: (2024)

Effect of time and temperature on the simultaneous formation of heterocyclic amines and polycyclic aromatic hydrocarbons using amino acid and sugar model systems
by: Ishak, Ainaatul Asmaa'
Published: (2021)

New preparations of diazo compounds and studies of their metal catalysed diverted insertion reactions
by: Nicolle, Simon
Published: (2016)

Toxicity and Degradation of Animal Antibiotic Residue in Soil
by: Yan, Wang
Published: (2010)

Utilization of antibiotics in primary healthcare setting / Shafinaz Shamsuddin
by: Shamsuddin, Shafinaz
Published: (2015)

Development of proline-based chiral ionic liquid organocatalyst for asymmetric Michael reaction under microwave irradiation
by: Omar, Emmy Maryati
Published: (2013)

Synthesis and biological evaluation of a series of analogues of 2,4,6-trihydroxy-3-geranylacetophenone, an anti-inflammatory natural product compound
by: Ng, Chean Hui
Published: (2017)

Antifungal Peptide Modeling, Folding and Mimetic Design
by: Moradi, Shoeib
Published: (2009)

Development of proteomic technique for potential species-specific peptide marker discovery of commercial seasoning cubes
by: Mohd Asri, Ummu Nasuha
Published: (2020)

One-pot ligation-oxidative deselenization at selenocysteine and selenocystine
by: Payne, Richard J., et al.
Published: (2017)

Effects of antibiotics on the anaerobic digestion process
by: Hawley, W.N.J.
Published: (2017)

Novel Synthesis Methods Using Phosphorus and Silicon Reagents
by: Thornton, Edward Alexander
Published: (2020)