Ipratropium is ‘luminally recycled’ by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers

QR Code

Ipratropium is ‘luminally recycled’ by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers

The mechanism by which quaternized anticholinergic bronchodilators permeate the airway epithelium remains controversial to date. In order to elucidate the role of drug transporters, ipratropium bidirectional transport as well as accumulation and release studies were performed in layers of the bronch...

Full description

Bibliographic Details
Main Authors:	Panduga, Vijender, Stocks, Michael J., Bosquillon, Cynthia
Format:	Article
Published:	Elsevier 2017
Subjects:	Drug inhalation Pulmonary drug delivery In vitro models Drug transporters Carrier-mediated transport Muscarinic M3 receptor antagonists
Online Access:	https://eprints.nottingham.ac.uk/46610/

Similar Items

Understanding the Lung Disposition of Inhaled Compounds using the Bronchial Epithelial Cell Culture Model Calu-3
by: Panduga, Vijender
Published: (2019)

Improving drug delivery to the lungs as a function of excipient choice
by: Olubi, Rebecca
Published: (2024)

Enhanced expression of Organic Cation Transporters in bronchial epithelial cell layers following insults associated with asthma – impact on salbutamol transport
by: Mukherjee, Manali, et al.
Published: (2017)

PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma
by: Luo, Tian, et al.
Published: (2016)

Formulation of chitosan-based nanoparticles for delivery of proteins and peptides
by: Vellore Janarthanan, Mohanraj
Published: (2003)

Understanding the roles and impact of Solute Carrier Transporters OCT1, OCTN1, and OCTN2 in lung epithelia
by: Magana Gomez, Paulyna Gabriela
Published: (2024)

Optimization of aptamer-based manganese doped zinc sulphide/chitosan and carbon dots/chitosan as drug nanocarriers for controlled release of Mitomycin C
by: Abd Manan, Fariza Aina
Published: (2024)

ABCG2: the lateral slice hypothesis as a model for multidrug transport
by: Cox, Megan H.
Published: (2019)

Synthesis and Evaluation of Lung Tissue Retentive Prodrugs
by: Ayre, Jack
Published: (2022)

Mathematical and computational models of drug transport in tumours
by: Groh, C.M., et al.
Published: (2014)

Development and application of in vitro approaches to assess the interactions of aerosolised drugs with pulmonary mucus
by: Alqahtani, Safar
Published: (2019)

Integration of an in vitro renal cellular set of tools with systems biology modelling to predict the renal contribution to the pharmacokinetics of a drug
by: Taylor, Patrick
Published: (2020)

Active search for computer-aided drug design
by: Oglic, Dino, et al.
Published: (2018)

Establishment of horse blood-brain barrier model for the study of drug delivery to the brain
by: Gupta, Gaurav
Published: (2025)

Drug delivery in a tumour cord model: a computational simulation
by: Hubbard, Matthew E., et al.
Published: (2017)

Characterisation of ATP-binding cassette (ABC) transporters in bronchial epithelial cell culture models
by: Hutter, Victoria
Published: (2012)

Design, Synthesis, and Evaluation of New P2Y2 Receptor Antagonists and Fluorescent Ligands
by: Knight, Rebecca
Published: (2025)

Kinetics of inhaled antibodies by gamma scintigraphy
by: Pereira, Catherine
Published: (2013)

Understanding the contribution of Resistance-Nodulation-Division family efflux pumps to the lifestyle of Pseudomonas aeruginosa
by: Scales, Danielle
Published: (2023)

Nebulized Furosemide for the Management of Dyspnea: Does the Evidence Support Its Use?
by: Newton, Phillip, et al.
Published: (2008)

Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer
by: Omran, Ziad, et al.
Published: (2017)

Investigating the role of Y-box binding protein 1 in medulloblastoma tumour progression and drug resistance
by: Taylor, Louisa
Published: (2022)

Oral lipid-based drug delivery approaches to improve the intestinal lymphatic transport and systemic bioavailability of a highly lipophilic drug cannabidiol
by: Feng, Wanshan
Published: (2022)

A comparative study of anti-doping law on athletes in Malaysia and The United States / Fadzlin Syaqinna Mazlan...[et al.]
by: Mazlan, Fadzlin Syaqinna, et al.
Published: (2013)

Modelling multidrug resistance driven by efflux pump expression in Gram-negative bacteria
by: Youlden, George
Published: (2021)

Drug utilization review among geriatric patients at primary care setting / Saidatul Sheeda Ahmad Shukri
by: Ahmad Shukri, Saidatul Sheeda
Published: (2015)

Evaluation of drug related problems in hospitalized acute coronary syndrome patients / Kuapih @ Florina Kimjun
by: Kimjun, Kuapih @ Florina
Published: (2014)

Assessment of pharmacists, public and general retailers perspectives, awareness and knowledge of registered drugs and unregistered drugs in Klang Valley / Nur Wahida Zulkifli
by: Zulkifli, Nur Wahida
Published: (2018)

Effective stress-shear strength interaction on the collapse behaviour of unsaturated residual soil grade v / Pooya Saffari
by: Saffari, Pooya
Published: (2018)

Analysis of adverse drug reactions related to drug-induced renal injury based on spontaneous adverse drug reactions reporting in Malaysia 2010 – 2014 / Nurulmaya Ahmad Sa'ad
by: Ahmad Sa'ad, Nurulmaya
Published: (2016)

Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
by: Mohd Salleh, Nurul Hidayah
Published: (2015)

An appraisal of the laws for the treatment and rehabilitation of drug dependants in Malaysia / Zafani Zainudin, Rozianti Mohamed Hanaphi and Tariq Azfar Maketab
by: Zainudin, Zafani, et al.
Published: (2007)

Vitamin D3-associated lyotropic liquid crystalline nanoparticles for gemcitabine and thymoquinone delivery for treatment of luminal breast cancer with resistant characteristics
by: Loo, Yan Shan
Published: (2023)

Learning lessons from adverse drug reactions in children
by: Sammons, Helen, et al.
Published: (2016)

Convulsive status epilepticus in children
by: Alotaibi, Khalid Nijr
Published: (2017)

An observational feasibility study of a new anaesthesia drug storage tray
by: Almghairbi, Dalal S., et al.
Published: (2018)

Encapsulation of hydrocortisone and mesalazine in zein microparticles
by: Lau, E., et al.
Published: (2013)

A multiscale analysis of drug transport and response for a multiphase tumor model
by: Collis, Joe, et al.
Published: (2016)

The suppression of illicit drugs through international law
by: Boister, Neil
Published: (1998)

Silk Road: Ebay for drugs
by: Barratt, Monica
Published: (2012)