Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study
Background: Evidence for risks of adverse maternal and birth outcomes in women with hyperemesis gravidarum (HG) is predominantly from small studies, unknown, or conflicting. Methods: A population-based cohort study using secondary health care records (Hospital Episode Statistics covering all of E...
| Main Authors: | , , , , |
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| Format: | Article |
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Wiley
2017
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| Online Access: | https://eprints.nottingham.ac.uk/46536/ |
| _version_ | 1848797349621530624 |
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| author | Fiaschi, Linda Nelson-Piercy, Catherine Gibson, Jack E. Szatkowski, Lisa Tata, Laila J. |
| author_facet | Fiaschi, Linda Nelson-Piercy, Catherine Gibson, Jack E. Szatkowski, Lisa Tata, Laila J. |
| author_sort | Fiaschi, Linda |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Evidence for risks of adverse maternal and birth outcomes in women with hyperemesis gravidarum (HG) is predominantly from small studies, unknown, or conflicting.
Methods: A population-based cohort study using secondary health care records (Hospital Episode Statistics covering all of England from 1997 to 2012) was used to calculate odds ratios (OR) with 99% confidence intervals (CI) for the association between HG hospital admission and adverse outcomes, adjusting for maternal and pregnancy confounders.
Results: Within 8 211 850 pregnancies ending in live births or stillbirths, women with HG had increased odds of anaemia (OR 1.28, 99% CI 1.23, 1.33), preeclampsia (OR 1.16, 99% CI 1.09, 1.22), eclampsia (OR 1.84, 99% CI 1.07, 3.18), venous thromboembolism antenatally (OR 1.94, 99% CI 1.57, 2.39 for deep vein thrombosis, and OR 2.54, 99% CI 1.89, 3.40 for pulmonary embolism) and post-partum. Odds of stillbirth (OR 0.77, 99% CI 0.66, 0.89) and post-term (OR 0.86, 99% CI 0.81, 0.92) delivery were decreased. Women were more likely to be induced (OR 1.20, 99% CI 1.16, 1.23), to deliver preterm (OR 1.11, 99% CI 1.05, 1.17), very preterm (OR 1.18, 99% CI 1.05, 1.32), or by caesarean section (OR 1.12, 99% CI 1.08, 1.16), to have low birthweight (OR 1.12, 99% CI 1.08, 1.17) or small for gestational age (OR 1.06, 99% CI 1.01, 1.11) babies and although absolute risks were small, their offspring were more likely to undergo resuscitation or neonatal intensive care.
Conclusion: HG may have important antenatal and postnatal consequences that should be considered in communications between health care professionals and women to best manage HG and prevent progression during pregnancy. |
| first_indexed | 2025-11-14T20:02:28Z |
| format | Article |
| id | nottingham-46536 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:02:28Z |
| publishDate | 2017 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-465362020-05-04T19:11:03Z https://eprints.nottingham.ac.uk/46536/ Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study Fiaschi, Linda Nelson-Piercy, Catherine Gibson, Jack E. Szatkowski, Lisa Tata, Laila J. Background: Evidence for risks of adverse maternal and birth outcomes in women with hyperemesis gravidarum (HG) is predominantly from small studies, unknown, or conflicting. Methods: A population-based cohort study using secondary health care records (Hospital Episode Statistics covering all of England from 1997 to 2012) was used to calculate odds ratios (OR) with 99% confidence intervals (CI) for the association between HG hospital admission and adverse outcomes, adjusting for maternal and pregnancy confounders. Results: Within 8 211 850 pregnancies ending in live births or stillbirths, women with HG had increased odds of anaemia (OR 1.28, 99% CI 1.23, 1.33), preeclampsia (OR 1.16, 99% CI 1.09, 1.22), eclampsia (OR 1.84, 99% CI 1.07, 3.18), venous thromboembolism antenatally (OR 1.94, 99% CI 1.57, 2.39 for deep vein thrombosis, and OR 2.54, 99% CI 1.89, 3.40 for pulmonary embolism) and post-partum. Odds of stillbirth (OR 0.77, 99% CI 0.66, 0.89) and post-term (OR 0.86, 99% CI 0.81, 0.92) delivery were decreased. Women were more likely to be induced (OR 1.20, 99% CI 1.16, 1.23), to deliver preterm (OR 1.11, 99% CI 1.05, 1.17), very preterm (OR 1.18, 99% CI 1.05, 1.32), or by caesarean section (OR 1.12, 99% CI 1.08, 1.16), to have low birthweight (OR 1.12, 99% CI 1.08, 1.17) or small for gestational age (OR 1.06, 99% CI 1.01, 1.11) babies and although absolute risks were small, their offspring were more likely to undergo resuscitation or neonatal intensive care. Conclusion: HG may have important antenatal and postnatal consequences that should be considered in communications between health care professionals and women to best manage HG and prevent progression during pregnancy. Wiley 2017-10-06 Article PeerReviewed Fiaschi, Linda, Nelson-Piercy, Catherine, Gibson, Jack E., Szatkowski, Lisa and Tata, Laila J. (2017) Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study. Paediatric and Perinatal Epidemiology, 32 (1). pp. 40-51. ISSN 1365-3016 http://onlinelibrary.wiley.com/doi/10.1111/ppe.12416/abstract doi:10.1111/ppe.12416 doi:10.1111/ppe.12416 |
| spellingShingle | Fiaschi, Linda Nelson-Piercy, Catherine Gibson, Jack E. Szatkowski, Lisa Tata, Laila J. Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study |
| title | Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study |
| title_full | Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study |
| title_fullStr | Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study |
| title_full_unstemmed | Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study |
| title_short | Adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: A population-based cohort study |
| title_sort | adverse maternal and birth outcomes in women admitted to hospital for hyperemesis gravidarum: a population-based cohort study |
| url | https://eprints.nottingham.ac.uk/46536/ https://eprints.nottingham.ac.uk/46536/ https://eprints.nottingham.ac.uk/46536/ |