Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes
Background and aims: We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. Methods and results: We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Earl...
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| Format: | Article |
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/46470/ |
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| author | Falconer, C.L. Cooper, A.R. Walhin, J.P. Thompson, D. Page, A.S. Peters, T.J. Montgomery, A.A. Sharp, D.J. Dayan, C.M. Andrews, R.C. |
| author_facet | Falconer, C.L. Cooper, A.R. Walhin, J.P. Thompson, D. Page, A.S. Peters, T.J. Montgomery, A.A. Sharp, D.J. Dayan, C.M. Andrews, R.C. |
| author_sort | Falconer, C.L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background and aims:
We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes.
Methods and results:
We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men.
Conclusions:
Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes. |
| first_indexed | 2025-11-14T20:02:13Z |
| format | Article |
| id | nottingham-46470 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:02:13Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-464702020-05-04T20:13:24Z https://eprints.nottingham.ac.uk/46470/ Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes Falconer, C.L. Cooper, A.R. Walhin, J.P. Thompson, D. Page, A.S. Peters, T.J. Montgomery, A.A. Sharp, D.J. Dayan, C.M. Andrews, R.C. Background and aims: We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. Methods and results: We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men. Conclusions: Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes. Elsevier 2014-09 Article NonPeerReviewed Falconer, C.L., Cooper, A.R., Walhin, J.P., Thompson, D., Page, A.S., Peters, T.J., Montgomery, A.A., Sharp, D.J., Dayan, C.M. and Andrews, R.C. (2014) Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases, 2014 (24(9)). pp. 956-962. ISSN 0939-4753 Sedentary time; Type 2 diabetes; Breaks in sedentary time; Inflammation http://www.sciencedirect.com/science/article/pii/S093947531400129X doi:10.1016/j.numecd.2014.03.009 doi:10.1016/j.numecd.2014.03.009 |
| spellingShingle | Sedentary time; Type 2 diabetes; Breaks in sedentary time; Inflammation Falconer, C.L. Cooper, A.R. Walhin, J.P. Thompson, D. Page, A.S. Peters, T.J. Montgomery, A.A. Sharp, D.J. Dayan, C.M. Andrews, R.C. Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes |
| title | Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes |
| title_full | Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes |
| title_fullStr | Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes |
| title_full_unstemmed | Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes |
| title_short | Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes |
| title_sort | sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes |
| topic | Sedentary time; Type 2 diabetes; Breaks in sedentary time; Inflammation |
| url | https://eprints.nottingham.ac.uk/46470/ https://eprints.nottingham.ac.uk/46470/ https://eprints.nottingham.ac.uk/46470/ |