Multitarget drug design strategy in Alzheimer’s disease: focus on cholinergic transmission and amyloid-β aggregation
Background: Alzheimer pathogenesis has been associated with a network of processes working simultaneously and synergistically. Over time, much interest has been focused on cholinergic transmission and its mutual interconnections with other active players of the disease. Besides the cholinesterase ma...
| Main Authors: | Simioni, Elena, Bartolini, Manuela, Abu, Izuddin Fahmy, Blockley, Alix, Gotti, Cecilia, Bottegoni, Giovanni, Caporaso, Roberta, Bergamini, Christian, Andrisano, Vincenza, Cavalli, Andrea, Mellor, Ian R., Minarini, Anna |
|---|---|
| Format: | Article |
| Published: |
Future Science
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/46445/ |
Similar Items
Multitarget Filtering With Unknown Clutter Density Using a Bootstrap GMCPHD Filter
by: Beard, Michael, et al.
Published: (2013)
by: Beard, Michael, et al.
Published: (2013)
Evaluation of AChE inhibitors and dual AChE/GSK3-β inhibitor as Alzheimer’s disease treatment
by: Uras, G
Published: (2021)
by: Uras, G
Published: (2021)
Development Of An Inhibitive Acetylcholinesterase-Based Assay For Insecticides
by: Tham, Lik Gin
Published: (2008)
by: Tham, Lik Gin
Published: (2008)
Clearing the amyloid in Alzheimer's: progress towards earlier diagnosis and effective treatments - an update for clinicians.
by: Asih, P., et al.
Published: (2014)
by: Asih, P., et al.
Published: (2014)
Phytochemical, cytotoxic and acetylcholinesterase inhibition in Kacip Fatimah (Labisia pumila (blume) fern.-vill.) penarahan (Horsfieldia superba (HK. F. & TH.) warb) and paku layar (Odontosoria chinensis (L.) J. SM.) extracts
by: Naji Al-Mekhlafi, Nabil Ali
Published: (2011)
by: Naji Al-Mekhlafi, Nabil Ali
Published: (2011)
Acetylcholinesterase from Osteochilus hasselti for the detection of insecticides and heavy metals
by: Sabullah, Mohd Khalizan
Published: (2011)
by: Sabullah, Mohd Khalizan
Published: (2011)
Antioxidant and antiacetylcholinesterase activities of Pluchea indica less
by: Ab. Rahim, Noridayu, et al.
Published: (2010)
by: Ab. Rahim, Noridayu, et al.
Published: (2010)
Molecular simulation between amyloid beta (1-42), a
Peptide associated with alzheimer disease, and zinc(ii) ion
by: Abdul Ghani, Nur Syafiqah
Published: (2016)
by: Abdul Ghani, Nur Syafiqah
Published: (2016)
The effectiveness of nicotine replacement therapy during pregnancy: investigating the role of nicotine substitution, nicotine metabolism and pregnant smokers’ experiences
by: Bowker, Katharine
Published: (2016)
by: Bowker, Katharine
Published: (2016)
Commentary on Taghavi et al. (2018): accurate measurement of tobacco smoke exposure and smoking behaviour matters
by: Coleman, Tim
Published: (2018)
by: Coleman, Tim
Published: (2018)
Atomic force microscopy investigations of peptide self-assembly
by: Sedman, Victoria L.
Published: (2006)
by: Sedman, Victoria L.
Published: (2006)
Applications of Dynamic nuclear polarisation in biological systems
by: Deo, Thomas Sandeep
Published: (2021)
by: Deo, Thomas Sandeep
Published: (2021)
The evolution of regulatory strategies in relation to nicotine products and their implications for product innovation and harm reduction
by: Rooke, Catriona
Published: (2011)
by: Rooke, Catriona
Published: (2011)
Purification and Characterization of Acetylcholinesterase from Clarias Batrachus and Oreochromis Mossambica Brain Tissues
by: Perumal, Natarajan
Published: (2006)
by: Perumal, Natarajan
Published: (2006)
Using primary care data to assess population-level estimates of maternal smoking and nicotine replacement therapy during pregnancy
by: Dhalwani, Nafeesa N.
Published: (2014)
by: Dhalwani, Nafeesa N.
Published: (2014)
The use of medicinal nicotine in pregnancy for smoking cessation
by: Vaz, Luis Reeves
Published: (2015)
by: Vaz, Luis Reeves
Published: (2015)
“Is it banned? Is it illegal?”: Navigating Western Australia's regulatory environment for e-cigarettes
by: McCausland, Kahlia, et al.
Published: (2021)
by: McCausland, Kahlia, et al.
Published: (2021)
Effects of Ramadan environment on nicotine dependence among Malay male smokers at a municipal council, Selangor, Malaysia
by: Zulkifley, Nuraisyah Hani
Published: (2017)
by: Zulkifley, Nuraisyah Hani
Published: (2017)
Protective effects of biochanin A on PC12 cells against Aβ and L-glutamate neurotoxicity
by: Tan, Ji Wei
Published: (2013)
by: Tan, Ji Wei
Published: (2013)
Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea
by: Nwidu, Lucky Legbosi, et al.
Published: (2017)
by: Nwidu, Lucky Legbosi, et al.
Published: (2017)
Effect of Ramadan environment on Fagerstrom Test For Nicotine Dependence (FTND) among smokers
by: Z., Nuraisyah Hani, et al.
Published: (2016)
by: Z., Nuraisyah Hani, et al.
Published: (2016)
Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
by: Xie, Ling, et al.
Published: (2002)
by: Xie, Ling, et al.
Published: (2002)
“They're sleek, stylish and sexy:” selling e-cigarettes online
by: Riwu Bara, Roy Pefi, et al.
Published: (2023)
by: Riwu Bara, Roy Pefi, et al.
Published: (2023)
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
by: Gunosewoyo, Hendra, et al.
Published: (2013)
by: Gunosewoyo, Hendra, et al.
Published: (2013)
Application of Dynamic Nuclear Polarisation and other advanced Magnetic Resonance methods for studies of Aβ(1-40) interactions with lipids
by: Connolly, Caitlin S
Published: (2024)
by: Connolly, Caitlin S
Published: (2024)
Post-prandial lipid metabolism, lipid-modulating agents and cerebrovascular integrity: Implications for dementia risk
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2010)
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2010)
Understanding pregnant smokers’ adherence to nicotine replacement therapy during a quit attempt: a qualitative study
by: Bowker, Katharine, et al.
Published: (2015)
by: Bowker, Katharine, et al.
Published: (2015)
Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II)
by: Wang, Jia, et al.
Published: (2018)
by: Wang, Jia, et al.
Published: (2018)
Changes in the rate of nicotine metabolism across pregnancy: a longitudinal study
by: Bowker, Katharine, et al.
Published: (2015)
by: Bowker, Katharine, et al.
Published: (2015)
Smoking relapse prevention: abstinence, relapse, current practice and effective interventions
by: Agboola, Shade
Published: (2017)
by: Agboola, Shade
Published: (2017)
Vaping topography, analysis of e-cigarette vapours and health risk assessment among current male users in selected population
by: Zainol Abidin, Najihah
Published: (2021)
by: Zainol Abidin, Najihah
Published: (2021)
Insecticide resistance mediated 1 by an exon skipping event
by: Berger, Madeleine, et al.
Published: (2016)
by: Berger, Madeleine, et al.
Published: (2016)
Changes in Brain Transcripts Related to Alzheimer’s Disease in a Model of HFE Hemochromatosis are not Consistent with Increased Alzheimer’s Disease Risk
by: Johnstone, D., et al.
Published: (2012)
by: Johnstone, D., et al.
Published: (2012)
Acetylcholinesterase activity measurement and clinical features of delirium
by: Jackson, T.A., et al.
Published: (2017)
by: Jackson, T.A., et al.
Published: (2017)
Prescribing of nicotine replacement therapy in and around pregnancy: a population-based study using primary care data
by: Dhalwani, Nafeesa N., et al.
Published: (2014)
by: Dhalwani, Nafeesa N., et al.
Published: (2014)
Nicotine replacement therapy in pregnancy and major congenital anomalies in offspring
by: Dhalwani, Nafeesa N., et al.
Published: (2015)
by: Dhalwani, Nafeesa N., et al.
Published: (2015)
Anti-inflammatory, anti-cholinergic and cytotoxic effects of Sida rhombifolia
by: Mah, Siau Hui, et al.
Published: (2017)
by: Mah, Siau Hui, et al.
Published: (2017)
The impact of lifestyle factors on the clinical outcomes of in vitro fertilisation-embryo transfer (IVF) treatment
by: Joesbury, Karen Ann
Published: (2003)
by: Joesbury, Karen Ann
Published: (2003)
Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial
by: Lindson-Hawley, Nicola, et al.
Published: (2014)
by: Lindson-Hawley, Nicola, et al.
Published: (2014)
Functional studies of insecticides and acaricides acting on ligand-gated ion channels
by: Iqbal, Sofia
Published: (2019)
by: Iqbal, Sofia
Published: (2019)
Similar Items
-
Multitarget Filtering With Unknown Clutter Density Using a Bootstrap GMCPHD Filter
by: Beard, Michael, et al.
Published: (2013) -
Evaluation of AChE inhibitors and dual AChE/GSK3-β inhibitor as Alzheimer’s disease treatment
by: Uras, G
Published: (2021) -
Development Of An Inhibitive Acetylcholinesterase-Based Assay For Insecticides
by: Tham, Lik Gin
Published: (2008) -
Clearing the amyloid in Alzheimer's: progress towards earlier diagnosis and effective treatments - an update for clinicians.
by: Asih, P., et al.
Published: (2014) -
Phytochemical, cytotoxic and acetylcholinesterase inhibition in Kacip Fatimah (Labisia pumila (blume) fern.-vill.) penarahan (Horsfieldia superba (HK. F. & TH.) warb) and paku layar (Odontosoria chinensis (L.) J. SM.) extracts
by: Naji Al-Mekhlafi, Nabil Ali
Published: (2011)