Application of a human primary epithelial-fibroblast co-culture system to study fibrosis

QR Code

Application of a human primary epithelial-fibroblast co-culture system to study fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disease which manifests over several years with an unknown aetiology. The current paradigm suggests that reoccurring injury to the lungs results in damage to the alveolar epithelial cells, progressing to the destruction of the alveol...

Full description

Bibliographic Details
Main Author:	Richardson, Jaineeta
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2017
Subjects:	Pulmonary fibrosis; Epithelial cells; Fibroblasts; Cell interactions
Online Access:	https://eprints.nottingham.ac.uk/46427/

Similar Items

Molecular mechanisms of enhanced expression of the chemokine interleukin 8 (CXCL8) in cystic fibrosis (CF) airway epithelial cells
by: Poghosyan, Anna
Published: (2014)

Spatiotemporal regulation of anti-remodelling signalling pathways in primary human lung fibroblasts
by: Roberts, Maxine
Published: (2020)

Characterisation of human bronchial epithelial response to injury and identification of potential resident progenitor cells in vitro
by: Nijmeh, Hala S.
Published: (2009)

International comparative epidemiology of idiopathic pulmonary fibrosis
by: Hutchinson, John
Published: (2017)

Interplay between EZH2 and G9a regulates CXCL10 gene repression in idiopathic pulmonary fibrosis
by: Coward, William R., et al.
Published: (2017)

Suberoylanilide hydroxamic acid – a potential epigenetic therapeutic agent for lung fibrosis?
by: Wang, Z., et al.
Published: (2009)

Modelling lymphangioleiomyomatosis (LAM) using two-dimensional and three-dimensional in vitro co-culture systems
by: Dongre, Arundhati
Published: (2018)

In vitro modelling of respiratory infections in idiopathic pulmonary fibrosis (IPF) using human induced pluripotent stem cell (hiPSCs)-derived alveolar epithelial type II cells
by: Serna Valverde, Ana Lilia
Published: (2023)

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis
by: Calver, J.F.
Published: (2023)

cAMP mediated regulation of fibroblast to myofibroblast differentiation in idiopathic pulmonary fibrosis
by: Wright, Rebecca
Published: (2016)

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response
by: Roberts, Maxine J., et al.
Published: (2018)

The influence of stromal fibroblast on antigen-presenting cell function and alteration of their biology
by: Mohammad, Salaheddin
Published: (2022)

Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricin
by: Robinson, Henry Duncan
Published: (2021)

In Vitro primary human airway epithelial whole exhaust exposure
by: Landwehr, Katherine R., et al.
Published: (2021)

Effects of synthetic 2, 4, 6-trihydroxy-3-geranylacetophenone upon TNF-α-induced epithelial dysfunction
by: Sim, Tee Yee
Published: (2016)

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review
by: Hutchinson, John P., et al.
Published: (2015)

The role of mesenchymal G proteins in pulmonary fibrosis and lung development
by: Goodwin, Amanda T.
Published: (2021)

Refining in-vivo models of pulmonary fibrosis
by: Habgood, Anthony
Published: (2018)

Characterisation of ATP-binding cassette (ABC) transporters in bronchial epithelial cell culture models
by: Hutter, Victoria
Published: (2012)

Evaluation of activity limitation in patients with idiopathic pulmonary fibrosis grouped according to Medical Research Council Dyspnea Grade
by: Kozu, R., et al.
Published: (2014)

Production of a sustainable primary airway cell model for respiratory research
by: O'Loughlin, Jonathan
Published: (2018)

Development of a sustainable primary human airway cell culture model for respiratory research
by: Lewis, A.
Published: (2018)

Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century
by: Hutchinson, John P., et al.
Published: (2014)

Developing stromal instructive niches to promote wound healing
by: Latif, Arsalan
Published: (2021)

Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells
by: Torr, Elizabeth, et al.
Published: (2016)

The role of Interleukin-33 in the development of idiopathic pulmonary fibrosis
by: Stephenson, Katherine
Published: (2021)

Use of a primary epithelial cell screening tool to investigate phage therapy in cystic fibrosis
by: Trend, S., et al.
Published: (2018)

Phenotypic change and induction of cytokeratin expression during in vitro culture of corneal stromal cells
by: Sidney, Laura E., et al.
Published: (2015)

Investigations into novel small molecules as potential treatments for idiopathic pulmonary fibrosis and malaria
by: Park, Jozef
Published: (2022)

Morphological differences between avian influenza viruses grown in chicken and duck cells, a comparative study
by: Al-Mubarak, Firas
Published: (2014)

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses
by: Slater, Tessa, et al.
Published: (2018)

Developing a chemically defined, xeno-free platform to differentiate human induced pluripotent stem cells to type 2 alveolar epithelial cells of the lung
by: Reed, Liam
Published: (2024)

ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis
by: Philp, Christopher J., et al.
Published: (2017)

Development and characterisation of optogenetic tools for non-invasive control of cellular functions in epithelia
by: Ciampani, Victoria
Published: (2019)

Development of a human induced pluripotent stem cells (hiPSCs)-derived, universal platform, for generation of immunocompetent multi-tissue organoids
by: Azis, Rizal
Published: (2024)

Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients
by: Ling, K.M., et al.
Published: (2019)

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
by: Aldajani, Wejdan A., et al.
Published: (2016)

Chloride intracellular channel 1 (CLIC1) contributes to modulation of cyclic AMP-activated whole cell chloride currents in human bronchial epithelial cells
by: Liu, Bo, et al.
Published: (2018)

Characterising the structural, functional and metabolomic changes occurring in human corneal cells due to Acanthamoeba castellanii secretome and amelioration of infection using cerium oxide nanoparticles
by: Alhazmi, Abdullah
Published: (2022)

The role of galectin-3 in the development of idiopathic pulmonary fibrosis
by: Parmar, Nimesh
Published: (2019)