Behavioral outcome measures to improve experimental stroke research
Functional recovery after an experimental stroke can be assessed by multiple behavioural tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioural compensation due to repe...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/46341/ |
| _version_ | 1848797305828802560 |
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| author | Balkaya, Mustafa G. Trueman, Rebecca C. Boltze, Johannes Corbett, Dale Jolkkonen, Jukka |
| author_facet | Balkaya, Mustafa G. Trueman, Rebecca C. Boltze, Johannes Corbett, Dale Jolkkonen, Jukka |
| author_sort | Balkaya, Mustafa G. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Functional recovery after an experimental stroke can be assessed by multiple behavioural tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioural compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success. |
| first_indexed | 2025-11-14T20:01:46Z |
| format | Article |
| id | nottingham-46341 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:01:46Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-463412020-05-04T18:57:22Z https://eprints.nottingham.ac.uk/46341/ Behavioral outcome measures to improve experimental stroke research Balkaya, Mustafa G. Trueman, Rebecca C. Boltze, Johannes Corbett, Dale Jolkkonen, Jukka Functional recovery after an experimental stroke can be assessed by multiple behavioural tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioural compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success. Elsevier 2017-07-29 Article PeerReviewed Balkaya, Mustafa G., Trueman, Rebecca C., Boltze, Johannes, Corbett, Dale and Jolkkonen, Jukka (2017) Behavioral outcome measures to improve experimental stroke research. Behavioural Brain Research . ISSN 1872-7549 Stroke Animal models Behavioral tests Sensorimotor function Cognition Depression Anxiety Restoration http://www.sciencedirect.com/science/article/pii/S0166432817307325?via%3Dihub doi:10.1016/j.bbr.2017.07.039 doi:10.1016/j.bbr.2017.07.039 |
| spellingShingle | Stroke Animal models Behavioral tests Sensorimotor function Cognition Depression Anxiety Restoration Balkaya, Mustafa G. Trueman, Rebecca C. Boltze, Johannes Corbett, Dale Jolkkonen, Jukka Behavioral outcome measures to improve experimental stroke research |
| title | Behavioral outcome measures to improve experimental stroke research |
| title_full | Behavioral outcome measures to improve experimental stroke research |
| title_fullStr | Behavioral outcome measures to improve experimental stroke research |
| title_full_unstemmed | Behavioral outcome measures to improve experimental stroke research |
| title_short | Behavioral outcome measures to improve experimental stroke research |
| title_sort | behavioral outcome measures to improve experimental stroke research |
| topic | Stroke Animal models Behavioral tests Sensorimotor function Cognition Depression Anxiety Restoration |
| url | https://eprints.nottingham.ac.uk/46341/ https://eprints.nottingham.ac.uk/46341/ https://eprints.nottingham.ac.uk/46341/ |