Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge

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Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge

The present study focused on inhibition of HSV-1 and -2 replication and pathogenesis in vitro and in vivo, through the selective targeting of the envelope glycoprotein D. Firstly, a human monoclonal antibody (Hu-mAb#33) was identified that could neutralise both HSV-1 and -2 at nM concentrations, inc...

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Bibliographic Details
Main Authors:	Clementi, Nicola, Criscuolo, Elena, Cappelletti, Francesca, Quaranta, Paola, Pistello, Mauro, Diotti, Roberta A., Sautto, Giuseppe A., Tarr, Alexander W., Mailland, Federico, Concas, Daniela, Burioni, Roberto, Clementi, Massimo, Mancini, Nicasio
Format:	Article
Published:	Elsevier 2017
Subjects:	HSV disseminated infection; Cell-to-cell virus transmission; Human antibodies; In vivo protection
Online Access:	https://eprints.nottingham.ac.uk/46065/

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