Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists

Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists

N-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide 1 was identified as a hit in a CCR4 receptor antagonist high throughput screen (HTS) of a sub-set of the AstraZeneca compound bank. As a hit with a lead-like profile, it was an excellent starting point for a CCR4 receptor antagonist p...

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Bibliographic Details
Main Authors: Kindon, Nicholas, Andrews, Glen, Baxter, Andrew, Cheshire, David, Hemsley, Paul, Johnson, Timothy, Liu, Yu-Zhen, McGinnity, Dermot, McHale, Mark, Mete, Antonio, Reuberson, James, Roberts, Bryan, Steele, John, Teobald, Barry, Unitt, John, Vaughan, Deborah, Walters, Iain, Stocks, Michael J.
Format: Article
Published: American Chemical Society 2017
Subjects:
Chemokine receptor 4; MDC; TARC; CCR4; Antagonist
Online Access:https://eprints.nottingham.ac.uk/45586/

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