Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists
N-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide 1 was identified as a hit in a CCR4 receptor antagonist high throughput screen (HTS) of a sub-set of the AstraZeneca compound bank. As a hit with a lead-like profile, it was an excellent starting point for a CCR4 receptor antagonist p...
Full description
Bibliographic Details
| Main Authors: |
Kindon, Nicholas,
Andrews, Glen,
Baxter, Andrew,
Cheshire, David,
Hemsley, Paul,
Johnson, Timothy,
Liu, Yu-Zhen,
McGinnity, Dermot,
McHale, Mark,
Mete, Antonio,
Reuberson, James,
Roberts, Bryan,
Steele, John,
Teobald, Barry,
Unitt, John,
Vaughan, Deborah,
Walters, Iain,
Stocks, Michael J. |
|---|
| Format: | Article
|
|---|
| Published: |
American Chemical Society
2017
|
|---|
| Subjects: | |
|---|
| Online Access: | https://eprints.nottingham.ac.uk/45586/
|
|---|