Injury among children and young adults with epilepsy
OBJECTIVE: To investigate whether children and young adults with epilepsy are at a greater risk of fracture, thermal injury, or poisoning than those without. METHODS: A cohort study was conducted by using the Clinical Practice Research Datalink (1987–2009), a longitudinal database containing primar...
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| Format: | Article |
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American Academy of Pediatrics
2014
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| Online Access: | https://eprints.nottingham.ac.uk/45284/ |
| _version_ | 1848797104054468608 |
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| author | Prasad, Vibhore Kendrick, Denise Sayal, Kapil Thomas, Sara L. West, Joe |
| author_facet | Prasad, Vibhore Kendrick, Denise Sayal, Kapil Thomas, Sara L. West, Joe |
| author_sort | Prasad, Vibhore |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | OBJECTIVE: To investigate whether children and young adults with epilepsy are at a greater risk of fracture, thermal injury, or poisoning than those without.
METHODS: A cohort study was conducted by using the Clinical Practice Research Datalink (1987–2009), a longitudinal database containing primary care records. A total of 11 934 people with epilepsy and 46 598 without, aged between 1 and 24 years at diagnosis, were followed for a median (interquartile range) of 2.6 (0.8–5.9) years. The risk of fractures (including long bone fractures), thermal injuries, and poisonings (including medicinal and nonmedicinal poisonings) was estimated.
RESULTS: Adjusting for age, gender, Strategic Health Authority region, deprivation, and calendar year at study entry (and, for medicinal poisonings, behavior disorder), people with epilepsy had an 18% increase in risk of fracture (hazard ratio [HR] = 1.18; 95% confidence interval [CI], 1.09–1.27), a 23% increase in risk of long bone fracture (HR = 1.23; 95% CI, 1.10–1.38), a 49% increase in risk of thermal injury (HR = 1.49; 95% CI, 1.27–1.75), and more than twice the risk of poisoning (HR = 2.47; 95% CI, 2.15–2.84), which was limited to poisoning from medicinal products (medicinal HR = 2.54; 95% CI, 2.16–2.99; nonmedicinal HR = 0.96; 95% CI, 0.61–1.52).
CONCLUSIONS: Children and young adults with epilepsy are at a greater risk of fracture, thermal injury, and poisoning than those without. The greatest risk is from medicinal poisonings. Doctors and other health care professionals should provide injury and poison prevention advice at diagnosis and epilepsy reviews. |
| first_indexed | 2025-11-14T19:58:34Z |
| format | Article |
| id | nottingham-45284 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:58:34Z |
| publishDate | 2014 |
| publisher | American Academy of Pediatrics |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-452842020-05-04T16:45:51Z https://eprints.nottingham.ac.uk/45284/ Injury among children and young adults with epilepsy Prasad, Vibhore Kendrick, Denise Sayal, Kapil Thomas, Sara L. West, Joe OBJECTIVE: To investigate whether children and young adults with epilepsy are at a greater risk of fracture, thermal injury, or poisoning than those without. METHODS: A cohort study was conducted by using the Clinical Practice Research Datalink (1987–2009), a longitudinal database containing primary care records. A total of 11 934 people with epilepsy and 46 598 without, aged between 1 and 24 years at diagnosis, were followed for a median (interquartile range) of 2.6 (0.8–5.9) years. The risk of fractures (including long bone fractures), thermal injuries, and poisonings (including medicinal and nonmedicinal poisonings) was estimated. RESULTS: Adjusting for age, gender, Strategic Health Authority region, deprivation, and calendar year at study entry (and, for medicinal poisonings, behavior disorder), people with epilepsy had an 18% increase in risk of fracture (hazard ratio [HR] = 1.18; 95% confidence interval [CI], 1.09–1.27), a 23% increase in risk of long bone fracture (HR = 1.23; 95% CI, 1.10–1.38), a 49% increase in risk of thermal injury (HR = 1.49; 95% CI, 1.27–1.75), and more than twice the risk of poisoning (HR = 2.47; 95% CI, 2.15–2.84), which was limited to poisoning from medicinal products (medicinal HR = 2.54; 95% CI, 2.16–2.99; nonmedicinal HR = 0.96; 95% CI, 0.61–1.52). CONCLUSIONS: Children and young adults with epilepsy are at a greater risk of fracture, thermal injury, and poisoning than those without. The greatest risk is from medicinal poisonings. Doctors and other health care professionals should provide injury and poison prevention advice at diagnosis and epilepsy reviews. American Academy of Pediatrics 2014-05-01 Article PeerReviewed Prasad, Vibhore, Kendrick, Denise, Sayal, Kapil, Thomas, Sara L. and West, Joe (2014) Injury among children and young adults with epilepsy. Pediatrics, 133 (5). pp. 827-835. ISSN 0031-4005 epilepsy injury fractures burns poisoning http://pediatrics.aappublications.org/content/133/5/827 doi:10.1542/peds.2013-2554 doi:10.1542/peds.2013-2554 |
| spellingShingle | epilepsy injury fractures burns poisoning Prasad, Vibhore Kendrick, Denise Sayal, Kapil Thomas, Sara L. West, Joe Injury among children and young adults with epilepsy |
| title | Injury among children and young adults with epilepsy |
| title_full | Injury among children and young adults with epilepsy |
| title_fullStr | Injury among children and young adults with epilepsy |
| title_full_unstemmed | Injury among children and young adults with epilepsy |
| title_short | Injury among children and young adults with epilepsy |
| title_sort | injury among children and young adults with epilepsy |
| topic | epilepsy injury fractures burns poisoning |
| url | https://eprints.nottingham.ac.uk/45284/ https://eprints.nottingham.ac.uk/45284/ https://eprints.nottingham.ac.uk/45284/ |