Controversial issues in the management of older adults with early breast cancer
It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/45140/ |
| _version_ | 1848797077826437120 |
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| author | Mislang, Anna Rachelle Cheung, Kwok-Leung Hamaker, Marije E. Kunkler, Ian Markopoulos, Christos Orecchia, Roberto Brain, Etienne Biganzoli, Laura |
| author_facet | Mislang, Anna Rachelle Cheung, Kwok-Leung Hamaker, Marije E. Kunkler, Ian Markopoulos, Christos Orecchia, Roberto Brain, Etienne Biganzoli, Laura |
| author_sort | Mislang, Anna Rachelle |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in less fit older patients where a conservative approach is commonly perceived to be more appropriate. The optimal management of this population is unknown and treatment decision should be personalized. This review article will discuss several controversial issues in managing older adults with early breast cancer in a multidisciplinary setting, including the role of surgical treatment of the axilla in clinically node negative disease, radiotherapy after breast conservation surgery in low-risk tumours, personalizing adjuvant systemic therapy, and geriatric assessments in breast cancer treatment decisions. |
| first_indexed | 2025-11-14T19:58:09Z |
| format | Article |
| id | nottingham-45140 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:58:09Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-451402020-05-04T18:49:16Z https://eprints.nottingham.ac.uk/45140/ Controversial issues in the management of older adults with early breast cancer Mislang, Anna Rachelle Cheung, Kwok-Leung Hamaker, Marije E. Kunkler, Ian Markopoulos, Christos Orecchia, Roberto Brain, Etienne Biganzoli, Laura It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in less fit older patients where a conservative approach is commonly perceived to be more appropriate. The optimal management of this population is unknown and treatment decision should be personalized. This review article will discuss several controversial issues in managing older adults with early breast cancer in a multidisciplinary setting, including the role of surgical treatment of the axilla in clinically node negative disease, radiotherapy after breast conservation surgery in low-risk tumours, personalizing adjuvant systemic therapy, and geriatric assessments in breast cancer treatment decisions. Elsevier 2017-06-09 Article PeerReviewed Mislang, Anna Rachelle, Cheung, Kwok-Leung, Hamaker, Marije E., Kunkler, Ian, Markopoulos, Christos, Orecchia, Roberto, Brain, Etienne and Biganzoli, Laura (2017) Controversial issues in the management of older adults with early breast cancer. Journal of Geriatric Oncology . ISSN 1879-4068 Older adults ; Early breast cancer ; Surgery ; Radiotherapy Chemotherapy ; Geriatric assessment http://www.sciencedirect.com/science/article/pii/S1879406817300978?via%3Dihub doi:10.1016/j.jgo.2017.05.004 doi:10.1016/j.jgo.2017.05.004 |
| spellingShingle | Older adults ; Early breast cancer ; Surgery ; Radiotherapy Chemotherapy ; Geriatric assessment Mislang, Anna Rachelle Cheung, Kwok-Leung Hamaker, Marije E. Kunkler, Ian Markopoulos, Christos Orecchia, Roberto Brain, Etienne Biganzoli, Laura Controversial issues in the management of older adults with early breast cancer |
| title | Controversial issues in the management of older adults with early breast cancer |
| title_full | Controversial issues in the management of older adults with early breast cancer |
| title_fullStr | Controversial issues in the management of older adults with early breast cancer |
| title_full_unstemmed | Controversial issues in the management of older adults with early breast cancer |
| title_short | Controversial issues in the management of older adults with early breast cancer |
| title_sort | controversial issues in the management of older adults with early breast cancer |
| topic | Older adults ; Early breast cancer ; Surgery ; Radiotherapy Chemotherapy ; Geriatric assessment |
| url | https://eprints.nottingham.ac.uk/45140/ https://eprints.nottingham.ac.uk/45140/ https://eprints.nottingham.ac.uk/45140/ |