Novel insight into uPAR function in the bronchial
epithelium in asthma using functional genomics

QR Code

Novel insight into uPAR function in the bronchial epithelium in asthma using functional genomics

The urokinase plasminogen activator receptor (uPAR, PLAUR) is a cell surface receptor actively involved in the regulation of cell homeostasis. Expression is elevated in the bronchial epithelium in vivo and also in serum and sputum in asthma and elevated expression often indicates poor prognosis in a...

Full description

Bibliographic Details
Main Author:	Bhaker, Sangita
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2017
Subjects:	uPAR; Cell surface receptors; Airway epithelium; Bronchial epithelial cells; Transcriptome analysis; Genetic polymorphisms; Asthma
Online Access:	https://eprints.nottingham.ac.uk/45133/

Similar Items

The role and regulation of the urokinase receptor in asthma and COPD
by: Portelli, Michael A.
Published: (2013)

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss
by: Chernyavsky, Igor L., et al.
Published: (2018)

The effects of endocannabinoids and phytocannabinoids on bronchial epithelial permeability
by: Shang, Valerie C.M.
Published: (2016)

Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma
by: Kicic, Anthony, et al.
Published: (2006)

Characterisation of human bronchial epithelial response to injury and identification of potential resident progenitor cells in vitro
by: Nijmeh, Hala S.
Published: (2009)

Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells
by: Torr, Elizabeth, et al.
Published: (2016)

Uptake and transport of B12-conjugated nanoparticles in airway epithelium
by: Fowler, Robyn, et al.
Published: (2013)

Chloride intracellular channel 1 (CLIC1) contributes to modulation of cyclic AMP-activated whole cell chloride currents in human bronchial epithelial cells
by: Liu, Bo, et al.
Published: (2018)

Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients
by: Ling, K.M., et al.
Published: (2019)

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
by: Jevnikar, Zala, et al.
Published: (2018)

The differential effects of azithromycin on the airway epithelium in vitro and in vivo
by: Slater, Mariel, et al.
Published: (2016)

Effects of synthetic 2, 4, 6-trihydroxy-3-geranylacetophenone upon TNF-α-induced epithelial dysfunction
by: Sim, Tee Yee
Published: (2016)

Development of a sustainable primary human airway cell culture model for respiratory research
by: Lewis, A.
Published: (2018)

Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium
by: Kicic, Anthony, et al.
Published: (2010)

Production of a sustainable primary airway cell model for respiratory research
by: O'Loughlin, Jonathan
Published: (2018)

The use of non-bronchoscopic brushings to study the paediatric airway
by: Lane, C., et al.
Published: (2005)

Nephronectin and the genetics of lung function variability
by: Qian, Guoqing
Published: (2023)

MMP-1 activation contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa, et al.
Published: (2017)

Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma
by: Donovan, G.M., et al.
Published: (2020)

Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium
by: Kicic, Anthony, et al.
Published: (2020)

Effects of 2,4,6-trihydroxy-3-geranyl acetophenone on growth factor-induced human bronchial smooth muscle cell proliferation in asthma
by: Yap, Hui Min
Published: (2018)

Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells
by: He, J.Q., et al.
Published: (2008)

Enhanced expression of Organic Cation Transporters in bronchial epithelial cell layers following insults associated with asthma – impact on salbutamol transport
by: Mukherjee, Manali, et al.
Published: (2017)

Folate-mediated macromolecule delivery across the epithelium
by: Moradi, Emilia
Published: (2012)

The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite
by: Shang, V.C.M., et al.
Published: (2016)

The role of histone arginine methylation in cytokine/chemokine gene expression in airway smooth muscle cells in asthma
by: Kaczmarek, Klaudia
Published: (2019)

Δ9-tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors
by: Shang, Valerie C.M., et al.
Published: (2016)

Limbal stem cells: The search for a marker
by: Chee, K.Y.H., et al.
Published: (2006)

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED
by: Khuo, Chih-Hsi Scott, et al.
Published: (2016)

Developing platforms for tissue engineering of the airways
by: Ramis, Jopeth
Published: (2020)

Development and characterisation of optogenetic tools for non-invasive control of cellular functions in epithelia
by: Ciampani, Victoria
Published: (2019)

A genome-wide regulatory network of INTS12 associated with pulmonary function
by: Kheirallah, Alexander K.
Published: (2017)

Pathway discovery using transcriptomic profiles in adult-onset severe asthma
by: Hekking, Pieter-Paul, et al.
Published: (2018)

Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells
by: Gough, Kevin C., et al.
Published: (2015)

Characterisation of ATP-binding cassette (ABC) transporters in bronchial epithelial cell culture models
by: Hutter, Victoria
Published: (2012)

Characterization of side population cells from human airway epithelium
by: Hackett, T.L., et al.
Published: (2008)

In Vitro primary human airway epithelial whole exhaust exposure
by: Landwehr, Katherine R., et al.
Published: (2021)

Developing a chemically defined, xeno-free platform to differentiate human induced pluripotent stem cells to type 2 alveolar epithelial cells of the lung
by: Reed, Liam
Published: (2024)

Cyclization enhances function of linear anti-arthritic peptides
by: Ali, Marina, et al.
Published: (2014)

Modelling cell–matrix interactions in airway smooth muscle cells
by: Irons, Linda
Published: (2019)