The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and animal welfare. It provides a number of recommendatio...

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Main Authors: Percie du Sert, Nathalie, Alfieri, Alessio, Allan, Stuart M., Carswell, Hilary V.O., Deuchar, Graeme A., Farr, Tracy D., Flecknell, Paul, Gallagher, Lindsay, Gibson, Claire L., Haley, Michael J., Macleod, Malcolm R., McColl, Barry W., McCabe, Christopher, Morancho, Anna, Moon, Lawrence D.F., O’Neill, Michael J., Pérez de Puig, Isabel, Planas, Anna, Ragan, C. Ian, Rosell, Anna, Roy, Lisa A., Ryder, Kathryn O., Simats, Alba, Sena, Emily S., Sutherland, Brad A., Tricklebank, Mark D., Trueman, Rebecca C., Whitfield, Lucy, Wong, Raymond, Macrae, I. Mhairi
Format: Article
Published: Nature Publishing Group 2017
Subjects:
3Rs
Animal welfare
Guidelines
Middle cerebral artery occlusion
Stroke
Online Access:https://eprints.nottingham.ac.uk/45121/

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