Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity
Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce the risk of bacterial colonization of the catheters for long-term users have not be...
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/45041/ |
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| author | Fisher, Leanne E. Hook, Andrew L. Ashraf, Waheed Yousef, Anfal Barrett, David A. Scurr, David J. Chen, Xinyong Smith, Emily F. Fay, Michael Parmenter, Christopher D.J. Parkinson, Richard Bayston, Roger |
| author_facet | Fisher, Leanne E. Hook, Andrew L. Ashraf, Waheed Yousef, Anfal Barrett, David A. Scurr, David J. Chen, Xinyong Smith, Emily F. Fay, Michael Parmenter, Christopher D.J. Parkinson, Richard Bayston, Roger |
| author_sort | Fisher, Leanne E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce the risk of bacterial colonization of the catheters for long-term users have not been successful, mainly because of the need for long duration of activity in flow conditions. Here we report the results of impregnation of urinary catheters with a combination of rifampicin, sparfloxacin and triclosan. In flow experiments, the antimicrobial catheters were able to prevent colonization by common uropathogens Proteus mirabilis, Staphylococcus aureus and Escherichia coli for 7 to 12 weeks in vitro compared with 1–3 days for other, commercially available antimicrobial catheters currently used clinically. Resistance development was minimized by careful choice of antimicrobial combinations. Drug release profiles and distribution in the polymer, and surface analysis were also carried out and the process had no deleterious effect on the mechanical performance of the catheter or its balloon. The antimicrobial catheter therefore offers for the first time a means of reducing infection and its complications in long-term urinary catheter users. |
| first_indexed | 2025-11-14T19:57:47Z |
| format | Article |
| id | nottingham-45041 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:57:47Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-450412020-05-04T17:03:49Z https://eprints.nottingham.ac.uk/45041/ Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity Fisher, Leanne E. Hook, Andrew L. Ashraf, Waheed Yousef, Anfal Barrett, David A. Scurr, David J. Chen, Xinyong Smith, Emily F. Fay, Michael Parmenter, Christopher D.J. Parkinson, Richard Bayston, Roger Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce the risk of bacterial colonization of the catheters for long-term users have not been successful, mainly because of the need for long duration of activity in flow conditions. Here we report the results of impregnation of urinary catheters with a combination of rifampicin, sparfloxacin and triclosan. In flow experiments, the antimicrobial catheters were able to prevent colonization by common uropathogens Proteus mirabilis, Staphylococcus aureus and Escherichia coli for 7 to 12 weeks in vitro compared with 1–3 days for other, commercially available antimicrobial catheters currently used clinically. Resistance development was minimized by careful choice of antimicrobial combinations. Drug release profiles and distribution in the polymer, and surface analysis were also carried out and the process had no deleterious effect on the mechanical performance of the catheter or its balloon. The antimicrobial catheter therefore offers for the first time a means of reducing infection and its complications in long-term urinary catheter users. Elsevier 2015-03-28 Article PeerReviewed Fisher, Leanne E., Hook, Andrew L., Ashraf, Waheed, Yousef, Anfal, Barrett, David A., Scurr, David J., Chen, Xinyong, Smith, Emily F., Fay, Michael, Parmenter, Christopher D.J., Parkinson, Richard and Bayston, Roger (2015) Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity. Journal of Controlled Release, 202 . pp. 57-64. ISSN 1873-4995 Antimicrobial; Bladder; Catheter infection; Drug release; Silicone; Urinary tract http://www.sciencedirect.com/science/article/pii/S0168365915000875?via%3Dihub doi:10.1016/j.jconrel.2015.01.037 doi:10.1016/j.jconrel.2015.01.037 |
| spellingShingle | Antimicrobial; Bladder; Catheter infection; Drug release; Silicone; Urinary tract Fisher, Leanne E. Hook, Andrew L. Ashraf, Waheed Yousef, Anfal Barrett, David A. Scurr, David J. Chen, Xinyong Smith, Emily F. Fay, Michael Parmenter, Christopher D.J. Parkinson, Richard Bayston, Roger Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity |
| title | Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity |
| title_full | Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity |
| title_fullStr | Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity |
| title_full_unstemmed | Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity |
| title_short | Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity |
| title_sort | biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity |
| topic | Antimicrobial; Bladder; Catheter infection; Drug release; Silicone; Urinary tract |
| url | https://eprints.nottingham.ac.uk/45041/ https://eprints.nottingham.ac.uk/45041/ https://eprints.nottingham.ac.uk/45041/ |