Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells
A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like ce...
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| Format: | Article |
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SAGE
2014
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| Online Access: | https://eprints.nottingham.ac.uk/44917/ |
| _version_ | 1848797027574480896 |
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| author | Pegg, Elise C. Matboli, Faisal Marriott, Tim Khan, Imran Scotchford, Colin |
| author_facet | Pegg, Elise C. Matboli, Faisal Marriott, Tim Khan, Imran Scotchford, Colin |
| author_sort | Pegg, Elise C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor. |
| first_indexed | 2025-11-14T19:57:21Z |
| format | Article |
| id | nottingham-44917 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:57:21Z |
| publishDate | 2014 |
| publisher | SAGE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-449172020-05-04T16:40:54Z https://eprints.nottingham.ac.uk/44917/ Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells Pegg, Elise C. Matboli, Faisal Marriott, Tim Khan, Imran Scotchford, Colin A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor. SAGE 2014-02-01 Article PeerReviewed Pegg, Elise C., Matboli, Faisal, Marriott, Tim, Khan, Imran and Scotchford, Colin (2014) Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells. Journal of Biomaterials Applications, 28 (6). pp. 946-953. ISSN 1530-8022 Fixation hydroxyapatite bone topography chemistry surface http://journals.sagepub.com/doi/10.1177/0885328213487410 doi:10.1177/0885328213487410 doi:10.1177/0885328213487410 |
| spellingShingle | Fixation hydroxyapatite bone topography chemistry surface Pegg, Elise C. Matboli, Faisal Marriott, Tim Khan, Imran Scotchford, Colin Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells |
| title | Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells |
| title_full | Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells |
| title_fullStr | Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells |
| title_full_unstemmed | Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells |
| title_short | Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells |
| title_sort | topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells |
| topic | Fixation hydroxyapatite bone topography chemistry surface |
| url | https://eprints.nottingham.ac.uk/44917/ https://eprints.nottingham.ac.uk/44917/ https://eprints.nottingham.ac.uk/44917/ |