Intensive versus guideline blood pressure and lipid lowering in patients with previous stroke: main results from the pilot ‘Prevention of decline in cognition after stroke trial’ (PODCAST) randomised controlled trial

QR Code

Intensive versus guideline blood pressure and lipid lowering in patients with previous stroke: main results from the pilot ‘Prevention of decline in cognition after stroke trial’ (PODCAST) randomised controlled trial

Background Stroke is associated with the development of cognitive impairment and dementia. We assessed the effect of intensive blood pressure (BP) and/or lipid lowering on cognitive outcomes in patients with recent stroke in a pilot trial. Methods In a multicentre, partial-factorial trial,...

Full description

Bibliographic Details
Main Authors:	Bath, Philip M.W., Scutt, Polly, Blackburn, Daniel J., Ankolekar, Sandeep, Krishnan, Kailash, Ballard, Clive, Burns, Alistair, Mant, Jonathan, Passmore, Peter, Pocock, Stuart, Reckless, John, Sprigg, Nikola, Stewart, Rob, Wardlaw, Joanna M., Ford, Gary A.
Format:	Article
Published:	Public Library of Science 2017
Online Access:	https://eprints.nottingham.ac.uk/44906/

Similar Items

Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST)
by: Scutt, Polly, et al.
Published: (2015)

Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial
by: Bath, Philip M.W., et al.
Published: (2014)

Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’
by: Scutt, Polly, et al.
Published: (2018)

Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053)
by: Appleton, Jason P., et al.
Published: (2017)

Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial
by: Dixon, Mark, et al.
Published: (2018)

The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research
by: Bath, Philip M.W., et al.
Published: (2016)

Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial
by: Bath, Philip M.W., et al.
Published: (2015)

Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials
by: Bath, Philip
Published: (2007)

The effect of transdermal glyceryl trinitrate in acute stroke patients with carotid stenosis: data from the Efficacy of Nitric Oxide in Stroke trial
by: Appleton, J.P., et al.
Published: (2018)

Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials
by: Bath, Philip M.W.
Published: (2007)

Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS)
by: Krishnan, Kailash, et al.
Published: (2018)

Speeding stroke recovery? A systematic review of amphetamine after stroke
by: Sprigg, Nikola, et al.
Published: (2009)

Granulocyte colony stimulating factor and physiotherapy after stroke: results of a feasibility randomised controlled trial: stem cell trial of recovery enhancement after Stroke-3 (STEMS-3 ISRCTN16714730)
by: Sprigg, Nikola, et al.
Published: (2016)

Effect of treatment delay, stroke type, and thrombolysis on the effect of glyceryl trinitrate, a nitric oxide donor, on outcome after acute stroke: a systematic review and meta-analysis of individual patient from randomised trials
by: Bath, Philip M.W., et al.
Published: (2016)

Remote Ischaemic Conditioning after Stroke Trial (RECAST): a pilot randomised placebo controlled phase II trial in acute ischaemic stroke (ISRCTN 86672015)
by: England, Timothy J., et al.
Published: (2017)

Sex differences in quality of life in stroke survivors. Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
by: Gray, Laura J., et al.
Published: (2007)

Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke
by: Woodhouse, Lisa J., et al.
Published: (2015)

Baseline characteristics of the 3,096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial
by: Bath, Philip M.W., et al.
Published: (2017)

Control of blood pressure after stroke
by: Bath, Philip M.W., et al.
Published: (2006)

Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
by: Sprigg, Nikola, et al.
Published: (2007)

Stroke severity, early recovery and outcome are each related with clinical classification of stroke: Data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
by: Sprigg, Nikola, et al.
Published: (2007)

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial
by: Flaherty, Katie, et al.
Published: (2017)

Serum amyloid protein is associated with outcome following acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (RECAST)
by: Appleton, Jason P., et al.
Published: (2018)

Blood pressure in acute stroke: to treat or not to treat - that is still the question
by: Bath, Philip M.W., et al.
Published: (2018)

Platelet and haemoglobin levels in patients on isosorbide mononitrate and/or cilostazol with lacunar ischaemic stroke: data from the LACI-1 trial
by: Appleton, Jason P., et al.
Published: (2018)

Consent procedures and relationship with outcome in the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)
by: Scutt, Polly, et al.
Published: (2018)

Results from the tranexamic acid for primary intracerebral haemorrhage-2 (TICH-2) trial
by: Sprigg, Nikola, et al.
Published: (2018)

Optimising the analysis of stroke trials
by: Gray, Laura Jayne
Published: (2008)

Adjudicating outcomes in stroke trials
by: Godolphin, Peter J.
Published: (2019)

Peripheral and central haemodynamics in patients on isosorbide mononitrate and/or cilostazol with lacunar ischaemic stroke: data from the LACI-1 trial
by: Appleton, Jason P., et al.
Published: (2018)

The Virtual International Stroke Trials Archive
by: Myzoon, Ali, et al.
Published: (2007)

Glyceryl trinitrate for acute intracerebral hemorrhage: results from the efficacy of nitric oxide in stroke (ENOS) trial, a subgroup analysis
by: Krishnan, Kailash, et al.
Published: (2015)

Impact of ultra/hyper-acute administration of glyceryl trinitrate on secondary outcome after acute stroke: a meta-analysis of individual patient data from randomised trials
by: Bath, Philip M., et al.
Published: (2018)

Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092)
by: Sprigg, Nikola, et al.
Published: (2006)

Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials
by: Optimising Analysis of Stroke Trials Collaboration, OAST
Published: (2007)

Blood pressure management in acute stroke
by: Appleton, Jason P., et al.
Published: (2016)

Continuing versus stopping prestroke antihypertensive therapy in acute intracerebral hemorrhage: a subgroup analysis of the efficacy of nitric oxide in stroke trial
by: Krishnan, Kailash, et al.
Published: (2016)

Route of feeding as a proxy for dysphagia after stroke and the effect of transdermal glyceryl trinitrate: data from the efficacy of nitric oxide in stroke randomised controlled trial
by: Woodhouse, Lisa J., et al.
Published: (2017)

Interim analysis of ambulance logistics and timings in patients recruited into the Rapid intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)
by: Dixon, Mark, et al.
Published: (2018)

Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor
by: Dixon, M., et al.
Published: (2018)