Neuropsychosocial profiles of current and future adolescent alcohol misusers
A comprehensive account of the causes of alcohol misuse must accommodate individual differences in biology, psychology and environment, and must disentangle cause and effect. Animal models1 can demonstrate the effects of neurotoxic substances; however, they provide limited insight into the psycho-so...
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| Format: | Article |
| Published: |
Nature Publishing Group
2014
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| Online Access: | https://eprints.nottingham.ac.uk/44855/ |
| _version_ | 1848797014281682944 |
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| author | Whelan, Robert Watts, Richard Orr, Catherine A. Althoff, Robert R. Artiges, Eric Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Büchel, Christian Carvalho, Fabiana M. Conrod, Patricia J. Flor, Herta Fauth-Bühler, Mira Frouin, Vincent Gallinat, Juergen Gan, Gabriela Gowland, Penny Heinz, Andreas Ittermann, Bernd Lawrence, Claire Mann, Karl Martinot, Jean-Luc Nees, Frauke Ortiz, Nick Paillère-Martinot, Marie-Laure Paus, Tomas Pausova, Zdenka Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Albrecht, Lisa Arroyo, Mercedes Aydin, Semiha Bach, Christine Barbot, Alexis Bricaud, Zuleima Bromberg, Uli Bruehl, Ruediger Cattrell, Anna Czech, Katharina Dalley, Jeffrey Desrivieres, Sylvane Fadai, Tahmine Fuchs, Birgit Gollier Briand, Fanny Head, Kay Heinrichs, Bert Heym, Nadja Hübner, Thomas Ihlenfeld, Albrecht Ireland, James Ivanov, Nikolay Jia, Tianye Jones, Jennifer Kepa, Agnes Lanzerath, Dirk Lathrop, Mark Lemaitre, Hervé Lüdemann, Katharina Martinez-Medina, Lourdes Mignon, Xavier Miranda, Ruben Müller, Kathrin Nymberg, Charlotte Pentilla, Jani Poline, Jean-Baptiste Poustka, Luise Rapp, Michael Ripke, Stephan Rodehacke, Sarah Rogers, John Romanowski, Alexander Ruggeri, Barbara Schmäl, Christine Schmidt, Dirk Schneider, Sophia Schroeder, Markus Schubert, Florian Sommer, Wolfgang Spanagel, Rainer Stacey, David Steiner, Sabina Stephens, Dai Strache, Nicole Struve, Maren Tahmasebi, Amir Topper, Lauren Vulser, Helene Walaszek, Bernadeta Werts, Helen Williams, Steve Peng Wong, C. Yacubian, Juliana Ziesch, Veronika |
| author_facet | Whelan, Robert Watts, Richard Orr, Catherine A. Althoff, Robert R. Artiges, Eric Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Büchel, Christian Carvalho, Fabiana M. Conrod, Patricia J. Flor, Herta Fauth-Bühler, Mira Frouin, Vincent Gallinat, Juergen Gan, Gabriela Gowland, Penny Heinz, Andreas Ittermann, Bernd Lawrence, Claire Mann, Karl Martinot, Jean-Luc Nees, Frauke Ortiz, Nick Paillère-Martinot, Marie-Laure Paus, Tomas Pausova, Zdenka Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Albrecht, Lisa Arroyo, Mercedes Aydin, Semiha Bach, Christine Barbot, Alexis Bricaud, Zuleima Bromberg, Uli Bruehl, Ruediger Cattrell, Anna Czech, Katharina Dalley, Jeffrey Desrivieres, Sylvane Fadai, Tahmine Fuchs, Birgit Gollier Briand, Fanny Head, Kay Heinrichs, Bert Heym, Nadja Hübner, Thomas Ihlenfeld, Albrecht Ireland, James Ivanov, Nikolay Jia, Tianye Jones, Jennifer Kepa, Agnes Lanzerath, Dirk Lathrop, Mark Lemaitre, Hervé Lüdemann, Katharina Martinez-Medina, Lourdes Mignon, Xavier Miranda, Ruben Müller, Kathrin Nymberg, Charlotte Pentilla, Jani Poline, Jean-Baptiste Poustka, Luise Rapp, Michael Ripke, Stephan Rodehacke, Sarah Rogers, John Romanowski, Alexander Ruggeri, Barbara Schmäl, Christine Schmidt, Dirk Schneider, Sophia Schroeder, Markus Schubert, Florian Sommer, Wolfgang Spanagel, Rainer Stacey, David Steiner, Sabina Stephens, Dai Strache, Nicole Struve, Maren Tahmasebi, Amir Topper, Lauren Vulser, Helene Walaszek, Bernadeta Werts, Helen Williams, Steve Peng Wong, C. Yacubian, Juliana Ziesch, Veronika |
| author_sort | Whelan, Robert |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A comprehensive account of the causes of alcohol misuse must accommodate individual differences in biology, psychology and environment, and must disentangle cause and effect. Animal models1 can demonstrate the effects of neurotoxic substances; however, they provide limited insight into the psycho-social and higher cognitive factors involved in the initiation of substance use and progression to misuse. One can search for pre-existing risk factors by testing for endophenotypic biomarkers2 in non-using relatives; however, these relatives may have personality or neural resilience factors that protect them from developing dependence3. A longitudinal study has potential to identify predictors of adolescent substance misuse, particularly if it can incorporate a wide range of potential causal factors, both proximal and distal, and their influence on numerous social, psychological and biological mechanisms4. Here we apply machine learning to a wide range of data from a large sample of adolescents (n = 692) to generate models of current and future adolescent alcohol misuse that incorporate brain structure and function, individual personality and cognitive differences, environmental factors (including gestational cigarette and alcohol exposure), life experiences, and candidate genes. These models were accurate and generalized to novel data, and point to life experiences, neurobiological differences and personality as important antecedents of binge drinking. By identifying the vulnerability factors underlying individual differences in alcohol misuse, these models shed light on the aetiology of alcohol misuse and suggest targets for prevention. |
| first_indexed | 2025-11-14T19:57:08Z |
| format | Article |
| id | nottingham-44855 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:57:08Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-448552020-05-04T16:51:31Z https://eprints.nottingham.ac.uk/44855/ Neuropsychosocial profiles of current and future adolescent alcohol misusers Whelan, Robert Watts, Richard Orr, Catherine A. Althoff, Robert R. Artiges, Eric Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Büchel, Christian Carvalho, Fabiana M. Conrod, Patricia J. Flor, Herta Fauth-Bühler, Mira Frouin, Vincent Gallinat, Juergen Gan, Gabriela Gowland, Penny Heinz, Andreas Ittermann, Bernd Lawrence, Claire Mann, Karl Martinot, Jean-Luc Nees, Frauke Ortiz, Nick Paillère-Martinot, Marie-Laure Paus, Tomas Pausova, Zdenka Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Albrecht, Lisa Arroyo, Mercedes Aydin, Semiha Bach, Christine Barbot, Alexis Bricaud, Zuleima Bromberg, Uli Bruehl, Ruediger Cattrell, Anna Czech, Katharina Dalley, Jeffrey Desrivieres, Sylvane Fadai, Tahmine Fuchs, Birgit Gollier Briand, Fanny Head, Kay Heinrichs, Bert Heym, Nadja Hübner, Thomas Ihlenfeld, Albrecht Ireland, James Ivanov, Nikolay Jia, Tianye Jones, Jennifer Kepa, Agnes Lanzerath, Dirk Lathrop, Mark Lemaitre, Hervé Lüdemann, Katharina Martinez-Medina, Lourdes Mignon, Xavier Miranda, Ruben Müller, Kathrin Nymberg, Charlotte Pentilla, Jani Poline, Jean-Baptiste Poustka, Luise Rapp, Michael Ripke, Stephan Rodehacke, Sarah Rogers, John Romanowski, Alexander Ruggeri, Barbara Schmäl, Christine Schmidt, Dirk Schneider, Sophia Schroeder, Markus Schubert, Florian Sommer, Wolfgang Spanagel, Rainer Stacey, David Steiner, Sabina Stephens, Dai Strache, Nicole Struve, Maren Tahmasebi, Amir Topper, Lauren Vulser, Helene Walaszek, Bernadeta Werts, Helen Williams, Steve Peng Wong, C. Yacubian, Juliana Ziesch, Veronika A comprehensive account of the causes of alcohol misuse must accommodate individual differences in biology, psychology and environment, and must disentangle cause and effect. Animal models1 can demonstrate the effects of neurotoxic substances; however, they provide limited insight into the psycho-social and higher cognitive factors involved in the initiation of substance use and progression to misuse. One can search for pre-existing risk factors by testing for endophenotypic biomarkers2 in non-using relatives; however, these relatives may have personality or neural resilience factors that protect them from developing dependence3. A longitudinal study has potential to identify predictors of adolescent substance misuse, particularly if it can incorporate a wide range of potential causal factors, both proximal and distal, and their influence on numerous social, psychological and biological mechanisms4. Here we apply machine learning to a wide range of data from a large sample of adolescents (n = 692) to generate models of current and future adolescent alcohol misuse that incorporate brain structure and function, individual personality and cognitive differences, environmental factors (including gestational cigarette and alcohol exposure), life experiences, and candidate genes. These models were accurate and generalized to novel data, and point to life experiences, neurobiological differences and personality as important antecedents of binge drinking. By identifying the vulnerability factors underlying individual differences in alcohol misuse, these models shed light on the aetiology of alcohol misuse and suggest targets for prevention. Nature Publishing Group 2014-07-02 Article PeerReviewed Whelan, Robert, Watts, Richard, Orr, Catherine A., Althoff, Robert R., Artiges, Eric, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Büchel, Christian, Carvalho, Fabiana M., Conrod, Patricia J., Flor, Herta, Fauth-Bühler, Mira, Frouin, Vincent, Gallinat, Juergen, Gan, Gabriela, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Lawrence, Claire, Mann, Karl, Martinot, Jean-Luc, Nees, Frauke, Ortiz, Nick, Paillère-Martinot, Marie-Laure, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Ströhle, Andreas, Schumann, Gunter, Garavan, Hugh, Albrecht, Lisa, Arroyo, Mercedes, Aydin, Semiha, Bach, Christine, Barbot, Alexis, Bricaud, Zuleima, Bromberg, Uli, Bruehl, Ruediger, Cattrell, Anna, Czech, Katharina, Dalley, Jeffrey, Desrivieres, Sylvane, Fadai, Tahmine, Fuchs, Birgit, Gollier Briand, Fanny, Head, Kay, Heinrichs, Bert, Heym, Nadja, Hübner, Thomas, Ihlenfeld, Albrecht, Ireland, James, Ivanov, Nikolay, Jia, Tianye, Jones, Jennifer, Kepa, Agnes, Lanzerath, Dirk, Lathrop, Mark, Lemaitre, Hervé, Lüdemann, Katharina, Martinez-Medina, Lourdes, Mignon, Xavier, Miranda, Ruben, Müller, Kathrin, Nymberg, Charlotte, Pentilla, Jani, Poline, Jean-Baptiste, Poustka, Luise, Rapp, Michael, Ripke, Stephan, Rodehacke, Sarah, Rogers, John, Romanowski, Alexander, Ruggeri, Barbara, Schmäl, Christine, Schmidt, Dirk, Schneider, Sophia, Schroeder, Markus, Schubert, Florian, Sommer, Wolfgang, Spanagel, Rainer, Stacey, David, Steiner, Sabina, Stephens, Dai, Strache, Nicole, Struve, Maren, Tahmasebi, Amir, Topper, Lauren, Vulser, Helene, Walaszek, Bernadeta, Werts, Helen, Williams, Steve, Peng Wong, C., Yacubian, Juliana and Ziesch, Veronika (2014) Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature, 512 (7513). pp. 185-189. ISSN 1476-4687 https://doi.org/10.1038/nature13402 doi:10.1038/nature13402 doi:10.1038/nature13402 |
| spellingShingle | Whelan, Robert Watts, Richard Orr, Catherine A. Althoff, Robert R. Artiges, Eric Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Büchel, Christian Carvalho, Fabiana M. Conrod, Patricia J. Flor, Herta Fauth-Bühler, Mira Frouin, Vincent Gallinat, Juergen Gan, Gabriela Gowland, Penny Heinz, Andreas Ittermann, Bernd Lawrence, Claire Mann, Karl Martinot, Jean-Luc Nees, Frauke Ortiz, Nick Paillère-Martinot, Marie-Laure Paus, Tomas Pausova, Zdenka Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Albrecht, Lisa Arroyo, Mercedes Aydin, Semiha Bach, Christine Barbot, Alexis Bricaud, Zuleima Bromberg, Uli Bruehl, Ruediger Cattrell, Anna Czech, Katharina Dalley, Jeffrey Desrivieres, Sylvane Fadai, Tahmine Fuchs, Birgit Gollier Briand, Fanny Head, Kay Heinrichs, Bert Heym, Nadja Hübner, Thomas Ihlenfeld, Albrecht Ireland, James Ivanov, Nikolay Jia, Tianye Jones, Jennifer Kepa, Agnes Lanzerath, Dirk Lathrop, Mark Lemaitre, Hervé Lüdemann, Katharina Martinez-Medina, Lourdes Mignon, Xavier Miranda, Ruben Müller, Kathrin Nymberg, Charlotte Pentilla, Jani Poline, Jean-Baptiste Poustka, Luise Rapp, Michael Ripke, Stephan Rodehacke, Sarah Rogers, John Romanowski, Alexander Ruggeri, Barbara Schmäl, Christine Schmidt, Dirk Schneider, Sophia Schroeder, Markus Schubert, Florian Sommer, Wolfgang Spanagel, Rainer Stacey, David Steiner, Sabina Stephens, Dai Strache, Nicole Struve, Maren Tahmasebi, Amir Topper, Lauren Vulser, Helene Walaszek, Bernadeta Werts, Helen Williams, Steve Peng Wong, C. Yacubian, Juliana Ziesch, Veronika Neuropsychosocial profiles of current and future adolescent alcohol misusers |
| title | Neuropsychosocial profiles of current and future adolescent alcohol misusers |
| title_full | Neuropsychosocial profiles of current and future adolescent alcohol misusers |
| title_fullStr | Neuropsychosocial profiles of current and future adolescent alcohol misusers |
| title_full_unstemmed | Neuropsychosocial profiles of current and future adolescent alcohol misusers |
| title_short | Neuropsychosocial profiles of current and future adolescent alcohol misusers |
| title_sort | neuropsychosocial profiles of current and future adolescent alcohol misusers |
| url | https://eprints.nottingham.ac.uk/44855/ https://eprints.nottingham.ac.uk/44855/ https://eprints.nottingham.ac.uk/44855/ |