Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound
Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/44743/ |
| _version_ | 1848796988661825536 |
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| author | Vaithilingam, Jayasheelan Kilsby, Samuel Goodridge, Ruth D. Christie, Steven D.R. Edmondson, Steve Hague, Richard J.M. |
| author_facet | Vaithilingam, Jayasheelan Kilsby, Samuel Goodridge, Ruth D. Christie, Steven D.R. Edmondson, Steve Hague, Richard J.M. |
| author_sort | Vaithilingam, Jayasheelan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications. |
| first_indexed | 2025-11-14T19:56:44Z |
| format | Article |
| id | nottingham-44743 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T19:56:44Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-447432017-10-16T01:21:45Z https://eprints.nottingham.ac.uk/44743/ Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound Vaithilingam, Jayasheelan Kilsby, Samuel Goodridge, Ruth D. Christie, Steven D.R. Edmondson, Steve Hague, Richard J.M. Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications. Elsevier 2015-01-01 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/44743/1/laser%201-s2.0-S0928493114006341-main.pdf Vaithilingam, Jayasheelan, Kilsby, Samuel, Goodridge, Ruth D., Christie, Steven D.R., Edmondson, Steve and Hague, Richard J.M. (2015) Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound. Materials Science and Engineering: C, 46 . pp. 52-61. ISSN 0928-4931 Selective laser melting (SLM) Self-assembled monolayers (SAMs) Additive manufacturing Functionalisation X-ray photoelectron spectroscopy (XPS) https://doi.org/10.1016/j.msec.2014.10.015 doi:10.1016/j.msec.2014.10.015 doi:10.1016/j.msec.2014.10.015 |
| spellingShingle | Selective laser melting (SLM) Self-assembled monolayers (SAMs) Additive manufacturing Functionalisation X-ray photoelectron spectroscopy (XPS) Vaithilingam, Jayasheelan Kilsby, Samuel Goodridge, Ruth D. Christie, Steven D.R. Edmondson, Steve Hague, Richard J.M. Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound |
| title | Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound |
| title_full | Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound |
| title_fullStr | Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound |
| title_full_unstemmed | Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound |
| title_short | Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound |
| title_sort | functionalisation of ti6al4v components fabricated using selective laser melting with a bioactive compound |
| topic | Selective laser melting (SLM) Self-assembled monolayers (SAMs) Additive manufacturing Functionalisation X-ray photoelectron spectroscopy (XPS) |
| url | https://eprints.nottingham.ac.uk/44743/ https://eprints.nottingham.ac.uk/44743/ https://eprints.nottingham.ac.uk/44743/ |